Intraperitoneal octenidindihydro-chloride-phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis model

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dc.contributor.authorGuezelsagqaltici, Nihat
dc.contributor.authorGirgin, Sadullah
dc.contributor.authorGedik, Ercan
dc.contributor.authorBueyuekbayram, Hueseyin
dc.contributor.authorBac, Bilsel
dc.date.accessioned2024-04-24T16:24:15Z
dc.date.available2024-04-24T16:24:15Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. Peritoneal adhesion is a common complication following abdominal surgery. Despite recent advances in diagnosis and treatment, it still presents a problem for the patients and surgeons. In the present study, we investigated the effects of octenidindihydro-chloride - phenoxyethanol (OCP) on peritoneal adhesions. Method. Rats were divided into four groups: Group 1 ( saline), Group 2 ( peritonitis plus saline), Group 3 ( OCP), and Group 4 ( peritonitis plus OCP). Peritonitis was induced in the rats of Groups 2 and 4. The abdominal cavities of the rats in Groups 1 and 2 were washed with saline, while those of the rats in Groups 3 and 4 were irrigated with 1: 10 OCP solution. Adhesion and fibrotic scores were determined by re-laparotomy after 21 days. Results. The adhesion scores in Groups 1 ( saline), 2 ( peritonitis plus saline), 3 (OCP) and 4 ( peritonitis plus OCP) were 3.30 +/- 0.94, 5.25 +/- 1.03, 1.12 +/- 0.83 and 0.28 +/- 0.48, respectively. Statistical analysis of adhesion scores revealed significant differences between groups, except between Groups 3 and 4 ( p = 0.265). Statistical analyses of grades of histopathological signs showed that Group 1 differed from Groups 2 and 4 ( p = 0.004, p = 0.003, respectively); Group 2 differed from Groups 3 and 4 ( p = 0.001, p = 0.001, respectively). On the other hand, differences between Group 3 and Groups 1 and 4 were not significant ( p = 0.06, p = 0.08, respectively). Conclusion. OCP decreased the peritoneal adhesion formation macroscopically and microscopically in the presence or absence of peritonitis. Peritoneal defects due to trauma are to be left open and OCP diluted 1: 1 should not be used intraperitoneally.en_US
dc.identifier.doi10.1080/00016340701267108
dc.identifier.endpage400en_US
dc.identifier.issn0001-6349
dc.identifier.issn1600-0412
dc.identifier.issue4en_US
dc.identifier.pmid17486458
dc.identifier.scopus2-s2.0-34248570098
dc.identifier.scopusqualityQ1
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.1080/00016340701267108
dc.identifier.urihttps://hdl.handle.net/11468/16613
dc.identifier.volume86en_US
dc.identifier.wosWOS:000246476400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Obstetricia Et Gynecologica Scandinavica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeritoneal Adhesionen_US
dc.subjectOctenidin Dihydrochloride-Phenoxyethanolen_US
dc.subjectPeritonitisen_US
dc.titleIntraperitoneal octenidindihydro-chloride-phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis modelen_US
dc.titleIntraperitoneal octenidindihydro-chloride-phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis model
dc.typeArticleen_US

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