The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine

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dc.contributor.authorÖztürk, H
dc.contributor.authorAldemir, M
dc.contributor.authorDokucu, AI
dc.contributor.authorYagmur, Y
dc.contributor.authorKilinç, N
dc.contributor.authorSahin, AH
dc.date.accessioned2024-04-24T16:00:10Z
dc.date.available2024-04-24T16:00:10Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractIt is suggested that gastrointestinal mucosal blood flow depends on a balanced release of vasoactive substances from the endothelium. The present study investigated the effects of molsidomine on the small intestine after ischemia-reperfusion (I/R) injury in four groups of 10 rats each composed: (1) SO, sham operation; (2) untreated I/R; (3) ML, I/R plus molsidomine pretreatment; (4) L-NAME, I/R plus N-omega-nitro-L-arginine methyl ester pretreatment. Intestinal ischemia for 45 min and reperfusion for 60 min were applied. Ileum specimens were obtained to determine the tissue level of malondialdehyde (MDA) and histologic changes. Mean MDA levels in the SO, untreated I/R, ML, and L-NAME groups were 95.60 +/- 2.59, 136.90 +/- 4.35, 121.10 +/- 3.38, and 137.40 +/- 4.42 nmol/g wet tissue, respectively. Although the MDA level in the ML group was higher than in the SO group (P < 0.0001), it was significantly lower compared to the untreated I/R and L-NAME groups (P < 0.0001, P < 0.0001). Mucosal injury scores (MIS) in groups 1-4 were 0.2 +/- 0.42, 3.9 +/- 0.73, 1.5 +/- 0.70, and 4.1 +/- 0.56, respectively. In group 3 the MIS was significantly lower than in groups 2 and 4 (P < 0.0001, P < 0.0001). Molsidomine plays a role in attenuating reperfusion injury of the small intestine by depression of tissue MDA levels and MIS and regulates post-ischemic intestinal perfusion while restoring the intestinal microcirculatory blood flow and histologic injury.en_US
dc.identifier.doi10.1007/s00383-002-0746-y
dc.identifier.endpage308en_US
dc.identifier.issn0179-0358
dc.identifier.issue4en_US
dc.identifier.pmid12783256
dc.identifier.scopus2-s2.0-0037818313
dc.identifier.scopusqualityQ2
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-002-0746-y
dc.identifier.urihttps://hdl.handle.net/11468/14392
dc.identifier.volume19en_US
dc.identifier.wosWOS:000183825800021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischemia And Reperfusion Injury Molsidomineen_US
dc.subjectNg-Monomethyl-L-Arginineen_US
dc.titleThe nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestineen_US
dc.titleThe nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine
dc.typeArticleen_US

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