Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target
Yükleniyor...
Dosyalar
Tarih
31.10.2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical role in promoting the survival and malignant behaviors of these cells. Estrogen signaling involves ligand-activated cytoplasmic estrogen receptors that translocate to the nucleus with various co-regulators, such as steroid receptor co-activator (SRC) family members, and bind to the promoters of target genes and regulate their expression. SRC-3 is a member of this family that interacts with, and enhances, the transcriptional activity of the ligand activated estrogen receptor. Although SRC-3 has important roles in normal homeostasis and developmental processes, it has been shown to be amplified and overexpressed in breast cancer and to promote malignancy. The malignancy-promoting potential of SRC-3 is diverse and involves both promoting malignant behavior of tumor cells and creating a tumor microenvironment that has an immunosuppressive phenotype. SRC-3 also inhibits the recruitment of tumor-infiltrating lymphocytes with effector function and promotes stemness. Furthermore, SRC-3 is also involved in the development of resistance to hormone therapy and immunotherapy during breast cancer treatment. The versatility of SRC-3 in promoting breast cancer malignancy in this way makes it a good target, and methodical targeting of SRC-3 probably will be important for the success of breast cancer treatment.
Açıklama
Anahtar Kelimeler
SRC-3, Breast cancer, Estrogen signaling, Tumor infiltrating cells, Tumor microenvironment
Kaynak
Cancers (Basel)
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
15
Sayı
21
Künye
Varışli L., Dancik G.M., Tolan V., Vlahopoulos S. (2023). Critical roles of SRC-3 in the development and progression of breast cancer, rendering it a prospective clinical target. Cancers (Basel). 15(21), 5242. doi: 10.3390/cancers15215242
