Outcomes of Turkish Ankylosing Spondylitis Patients

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dc.contributor.authorInanir, Ahmet
dc.contributor.authorYigit, Serbulent
dc.contributor.authorSariyildiz, Mustafa Akif
dc.contributor.authorSogut, Erkan
dc.date.accessioned2024-04-24T17:20:23Z
dc.date.available2024-04-24T17:20:23Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAnkylosing spondylitis (AS) is chronic, progressive, systemic inflammatory rheumatic diseases that lead to serious disability. The objective of this study was to determine the demographic, clinic characteristics and CYP2D6*4 gene mutation profiles of the AS patients in Tokat, Turkey. In this retrospective study, we evaluated 103 patients that were diagnosed and followed up as AS in Tokat, Turkey between 2008-2011. Demographical properties (age, sex, education level, age at diagnosis, disease duration), clinical characteristics (HLA27, peripheral/extraarticular involvoment, chest expansion, enthesopathy, modified schouber) and genetic analysis results (CYP2D6*4 gene mutation frequency) of AS patients were assessed. The mean age of AS patients was 36.80 +/- 9.25 years. The mean age of female and male 39.10 +/- 7.89, 35.40 +/- 9.79 respectively. The female to male ratio was 1: 1.6. Major histocompatibility complex, class I, B 27 (HLAB27) was investigated and the rate of positivity was 73.78 %. There was a statistically significant difference between CYP2D6 gene mutation and peripheral /extraarticular involvement (p<0.05). Determining the clinical characteristics and CYP2D6*4 gene mutations of rheumatologic diseases as AS will provide benefits for early diagnosis, treatment, and disease outcome.en_US
dc.identifier.doi10.29333/ejgm/82245
dc.identifier.endpage149en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84887344460
dc.identifier.scopusqualityN/A
dc.identifier.startpage145en_US
dc.identifier.trdizinid162124
dc.identifier.urihttps://doi.org/10.29333/ejgm/82245
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/162124
dc.identifier.urihttps://hdl.handle.net/11468/19009
dc.identifier.volume10en_US
dc.identifier.wosWOS:000421931100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectCyp2d6 Geneen_US
dc.subjectClinical Characteristicsen_US
dc.titleOutcomes of Turkish Ankylosing Spondylitis Patientsen_US
dc.titleOutcomes of Turkish Ankylosing Spondylitis Patients
dc.typeArticleen_US

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