Alterations of the neutrophil-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients

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dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorDemir, Melike
dc.contributor.authorKaya, Halide
dc.contributor.authorSen, Hadice Selimoglu
dc.contributor.authorAbakay, Ozlem
dc.contributor.authorCarkanat, Ali Ihsan
dc.contributor.authorAbakay, Abdurrrahman
dc.date.accessioned2024-04-24T17:11:26Z
dc.date.available2024-04-24T17:11:26Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectivesWe aimed to investigate the importance of neutrophil-lymphocyte ratio (NLR) in patients with chronic obstructive pulmonary disease (COPD) for identifying the severity of inflammation and recognition of acute exacerbation. MethodsWe retrospectively enrolled 100 patients with a diagnosis of COPD exacerbation who were admitted to our clinic. Complete blood count (CBC), measurement of C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were determined within 2 h of hospital admission. Three months after an acute exacerbation, these measurements were obtained from the same patients during the stable period of COPD. The control group included 80 healthy subjects. NLR was calculated from CBC. ResultsNLR and other inflammatory markers, such as WBC, CRP and ESR were found to be significantly elevated in exacerbated COPD compared to stable COPD and control participants. There was a significant correlation of NLR with CRP (r=0.415, P<0.001), WBC (r=0.304, P=0.002) and ESR (r=0.275, P=0.035). For an NLR cutoff of 3.29, sensitivity for detecting exacerbation of COPD was 80.8% and specificity was 77.7% (AUC 0.894, P=0.001). Some patients presenting with acute exacerbation of COPD and CRP, WBC or ESR levels lower than the optimal cut-off value had high NLR values. ConclusionsElevated NLR can be used as a marker similar to CRP, WBC and ESR, in the determination of increased inflammation in acutely exacerbated COPD. NLR could be beneficial for the early detection of potential acute exacerbations in patients with COPD who have normal levels of traditional markers.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipThis submission has not been published anywhere previously and is not simultaneously being considered for any other publication. The authors report no declaration of intrests. We are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.doi10.1111/crj.12336
dc.identifier.endpage317en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue3en_US
dc.identifier.pmid26096858
dc.identifier.scopus2-s2.0-84938810958
dc.identifier.scopusqualityQ3
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1111/crj.12336
dc.identifier.urihttps://hdl.handle.net/11468/17517
dc.identifier.volume11en_US
dc.identifier.wosWOS:000400580500005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeutrophil-Lymphocyte Ratioen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectInflammationen_US
dc.subjectMarkeren_US
dc.subjectAcute Exacerbationen_US
dc.subjectComplete Blood Counten_US
dc.titleAlterations of the neutrophil-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patientsen_US
dc.titleAlterations of the neutrophil-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients
dc.typeArticleen_US

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