Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis

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dc.contributor.authorTurgut, A.
dc.contributor.authorOzler, A.
dc.contributor.authorGoruk, N. Y.
dc.contributor.authorTunc, S. Y.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorGul, T.
dc.date.accessioned2024-04-24T17:33:25Z
dc.date.available2024-04-24T17:33:25Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To compare patients with advanced stage endometriosis with control patients without endometriosis with respect to serum Copper (Cu) and Ceruloplasmin (Cp) levels and oxidative stress markers in order to evaluate the importance of these parameters in the pathogenesis of endometriosis. PATIENTS AND METHODS: A total of 72 women who underwent laparoscopy or laparotomy for evaluation of infertility, pelvic pain, pelvic mass, tubal ligation or endometriosis were enrolled for this prospective clinical study. Patients were divided into two groups by visual diagnosis at surgery and histological confirmation of endometriosis: control patients (n=41) without endometriosis and study group (n=31) with stage III/IV (advanced stage) endometriosis. Serum Cu, Cp, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), malondialdehyde (MDA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were compared between the two groups. Correlations between Cu, Cp and oxidative stress markers were determined. RESULTS: Serum TOS, OSI, Cu, Cp, TG, TC, LDL were significantly higher, whereas TAS, PON-1 activity and HDL were significantly lower, in women with advanced-stage endometriosis than in control groups. There was no difference in serum MDA activities between the two groups. Positive correlations were found between Cu and TOS, Cu and OSI, Cu and Cp, while a negative correlation was found between Cu and PON-1 in the advanced-stage endometriosis group. Positive correlations were found between Cp and TOS, and Cp and OSI in the advanced-stage endometriosis group. CONCLUSIONS: Cu and Cp appear to be associated with the etiopathogenesis of and oxidative stress in endometriosis.en_US
dc.identifier.endpage1478en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid23771536
dc.identifier.scopus2-s2.0-84883468467
dc.identifier.scopusqualityQ2
dc.identifier.startpage1472en_US
dc.identifier.urihttps://hdl.handle.net/11468/20678
dc.identifier.volume17en_US
dc.identifier.wosWOS:000324923500006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopperen_US
dc.subjectCeruloplasminen_US
dc.subjectOxidative Stressen_US
dc.subjectEndometriosisen_US
dc.titleCopper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosisen_US
dc.titleCopper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis
dc.typeArticleen_US

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