Protective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerve

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dc.contributor.authorYucel, Yavuz
dc.contributor.authorCelepkolu, Tahsin
dc.contributor.authorKibrisli, Erkan
dc.contributor.authorKilinc, Faruk
dc.contributor.authorBeyaz, Coskun
dc.contributor.authorAluclu, Mehmet Ufuk
dc.contributor.authorBasarili, Mustafa Kemal
dc.date.accessioned2024-04-24T17:21:14Z
dc.date.available2024-04-24T17:21:14Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThere has been no report which investigates the effects of Caffeic Acid Phenethyl Ester (CAPE) on elevated levels of oxidative stress in sciatic nerve tissues of diabetic rats. Therefore, this study was undertaken to determine whether CAPE, by virtue of its antioxidant properties, could affect lipid peroxidation, nitric oxide (NO), Paraoxonase (PON-1) and the oxidant/antioxidant balance in the sciatic nerve of Streptozotocin (STZ)-induced diabetic rats. The rats were treated as follows: control; this group of rats (n = 9) received isotonic solution. Diabetic (STZ, untreated diabetic): STZ 50 mg kg(-1) b.wt. was given intraperitoneally for the induction to this group (n = 8). Diabetic+CAPE treatment (STZ+CAPE, CAPE-treated diabetic): diabetic rats (n = 8) received CAPE (10 mu mol/kg/day) for a period of 21 days beginning one week after the STZ administration. Biomarkers; Malondialdehyde (MDA), Total Oxidant Status (TOS), total antioxidant status (TAS), PON-1 and NO levels for oxidative stress in sciatic nerve of the rats were measured. We found a significant increase in MDA, NO and TOS levels along with a reduction in TAS levels and PON-1 activity in the sciatic nerves of the STZ-induced diabetic rats (at p<0.001). The MDA, TOS and NO levels in sciatic nerve were significantly reduced in the CAPE-treated diabetic group compared to the untreated diabetic group (at p<0.05). In conclusion, the results of this study demonstrated that CAPE exhibits protective effects against oxidative damage in the sciatic nerve tissues of diabetic rats.en_US
dc.identifier.doi10.3923/ijp.2012.577.581
dc.identifier.endpage581en_US
dc.identifier.issn1811-7775
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84866135243
dc.identifier.scopusqualityN/A
dc.identifier.startpage577en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2012.577.581
dc.identifier.urihttps://hdl.handle.net/11468/19411
dc.identifier.volume8en_US
dc.identifier.wosWOS:000316977400018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic Raten_US
dc.subjectSciatic Nerveen_US
dc.subjectOxidative Stressen_US
dc.subjectCurcuminen_US
dc.titleProtective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerveen_US
dc.titleProtective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerve
dc.typeArticleen_US

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