Impact of chromium histidinate on high fat diet induced obesity in rats

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dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhan
dc.contributor.authorOrhan, Cemal
dc.contributor.authorAgca, Can Ali
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorTuzcu, Zeynep
dc.contributor.authorKomorowski, James
dc.date.accessioned2024-04-24T17:14:53Z
dc.date.available2024-04-24T17:14:53Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Chromium (Cr) is an essential trace element that has garnered interest for use as a weight loss aid, but its molecular mechanism in obesity is not clear. In this study, an attempt has been made to investigate the effects of chromium histidinate (CrHis) on glucose transporter-2 (GLUT-2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), nuclear factor-kappa B (NF-kappa B p65) and the oxidative stress marker 4-hydroxynonenal adducts (HNE) expressions in liver of rats fed high fat diet (HFD). Methods: Male Wistar rats (n = 40, 8 wk-old) were divided into four groups. Group I was fed a standard diet (12% of calories as fat); Group II was fed a standard diet and supplemented with 110 mu g CrHis/kg BW/d; Group III was fed a HFD (40% of calories as fat); Group IV was fed HFD and supplemented with 110 mu g CrHis/kg BW/d. Results: Rats fed HFD possessed greater serum insulin (40 vs. 33 pmol/L) and glucose (158 vs. 143 mg/dL) concentration and less liver Cr (44 vs. 82 mu g/g) concentration than rats fed the control diet. However, rats supplemented with CrHis had greater liver Cr and serum insulin and lower glucose concentration in rats fed HFD (P < 0.05). The hepatic nuclear factor-kappa B (NF-kappa B p65) and HNE were increased in high fat group compared to control group, but reduced by the CrHis administration (P < 0.05). The levels of hepatic Nrf2 and HO-1 were increased by supplementation of CrHis (P < 0.05). Conclusion: These findings demonstrate that supplementation of CrHis is protective against obesity, at least in part, through Nrf2-mediated induction of HO-1 in rats fed high fat diet.en_US
dc.description.sponsorshipNutrition 21, Inc., NY, USAen_US
dc.description.sponsorshipThe study was funded by Nutrition 21, Inc., NY, USA. Nutrition 21 also supplied the chromium histidinate used in the study. James Komorowskiis an employee of Nutrition 21, the distributors of chromium histidinateunder a license from the USDA.en_US
dc.identifier.doi10.1186/1743-7075-8-28
dc.identifier.issn1743-7075
dc.identifier.pmid21539728
dc.identifier.scopus2-s2.0-79955487068
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/1743-7075-8-28
dc.identifier.urihttps://hdl.handle.net/11468/18240
dc.identifier.volume8en_US
dc.identifier.wosWOS:000290715900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofNutrition & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleImpact of chromium histidinate on high fat diet induced obesity in ratsen_US
dc.titleImpact of chromium histidinate on high fat diet induced obesity in rats
dc.typeArticleen_US

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