Effects of Intra-Abdominal Hypertension on the Endocrine Functions of the Pancreas in Rats

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dc.contributor.authorBoyuk, Abdullah
dc.contributor.authorBalik, Ahmet
dc.contributor.authorGumus, Metehan
dc.contributor.authorErdogan, Fazli
dc.contributor.authorGumustekin, Kenan
dc.contributor.authorKiziltunc, Ahmet
dc.contributor.authorPolat, Kamil Yalcin
dc.date.accessioned2024-04-24T17:08:36Z
dc.date.available2024-04-24T17:08:36Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Intra-abdominal hypertension (IAH) has negative effects on the functions of intra-and extra-abdominal organs and systems. Intra-and extraperitoneal hemorrhage, diffuse intestinal and retroperitoneal edema, intestinal ileus or obstruction, necrotizing pancreatitis, intra-abdominal packing, intra-abdominal sepsis, and pneumoperitoneum can all cause IAH. No studies were found in the literature relating to the effects of IAH on the endocrine functions of the pancreas. Therefore, the objective of this study was to investigate the effects of IAH on the endocrine functions of the pancreas. Methods: Forty male rats were divided into four groups: control, sham control, and two study groups, each containing 10 rats. In one of the study groups, animals were subjected to IAH of up to 20 mm Hg and in the other study group to 25 mm Hg, for 3 hours. At the end of the study, blood samples were collected for biochemical analysis and pancreatic tissue samples for histopathologic examination. Results: The results showed that glucagon levels were increased in the study groups (p < 0.001) and insulin levels were decreased (p < 0.001). There were no differences between the control and sham control groups. Histopathologic examination showed inflammatory cell infiltration in exocrine pancreatic tissue and vascular congestion in the islets of Langerhans. Conclusion: IAH causes an increase in glucagon levels and a decrease in insulin levels. These changes may be due to both the direct effects of IAH and the indirect effects of other organs that are affected by IAH.en_US
dc.identifier.doi10.1097/TA.0b013e31820d0a57
dc.identifier.endpageE98en_US
dc.identifier.issn0022-5282
dc.identifier.issn1529-8809
dc.identifier.issue4en_US
dc.identifier.pmid21610536
dc.identifier.scopus2-s2.0-80054037886
dc.identifier.scopusqualityN/A
dc.identifier.startpageE94en_US
dc.identifier.urihttps://doi.org/10.1097/TA.0b013e31820d0a57
dc.identifier.urihttps://hdl.handle.net/11468/17394
dc.identifier.volume71en_US
dc.identifier.wosWOS:000295925700004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Trauma-Injury Infection and Critical Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbdominal Compartment Syndromeen_US
dc.subjectIntra-Abdominal Hypertensionen_US
dc.subjectEndocrine Pancreasen_US
dc.titleEffects of Intra-Abdominal Hypertension on the Endocrine Functions of the Pancreas in Ratsen_US
dc.titleEffects of Intra-Abdominal Hypertension on the Endocrine Functions of the Pancreas in Rats
dc.typeArticleen_US

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