Oral intralipid emulsion use: a novel therapeutic approach to pancreatic ?-cell injury caused by malathion toxicity in rats

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dc.contributor.authorTuzcu, Kasim
dc.contributor.authorAlp, Harun
dc.contributor.authorOzgur, Tumay
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorDavarci, Isil
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorKarakus, Ali
dc.date.accessioned2024-04-24T17:20:26Z
dc.date.available2024-04-24T17:20:26Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to investigate whether oral intralipid emulsion (OIE) reduces pancreatic beta-cell injury (P beta CI) by chelating with malathion (M), or increases P beta CI by increasing M absorption in the stomach. Fifty rats were randomly divided into six groups: control group (C); OIE administered group (L); M-treated group (M); OIE-administered group immediately after given M (M0L); OIE-administered group 6 hours after being given M (M6L) and OIE administered group 12 hours after being given M (M12L). M induced P beta CI, hyperglycemia, temporary hyperinsulinemia and oxidative stress (OS). However, there was no significant difference in serum levels of glucose, insulin, total oxidants (TOS) and liver TOS between the M0L group and groups C and L. Also, insulin levels of M12L significantly increased, compared to the M6L group. Biochemical results, which were confirmed by histopathology, indicate that administering OIE after 6 hours and immediately after taking M may markedly prevent P beta CI, hyperglycemia and OS. In addition, OIE's effectiveness decreased after 6 hours and was totally ineffective after 12 hours. We concluded that OIE may help to achieve a better prognosis and reduce mortality rate in cases presented to the emergency department, particularly within the first 6 hours, resulting from organophosphate pesticide poisoning by oral ingestion.en_US
dc.identifier.doi10.3109/01480545.2013.838780
dc.identifier.endpage267en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid24180244
dc.identifier.scopus2-s2.0-84901947694
dc.identifier.scopusqualityQ1
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.3109/01480545.2013.838780
dc.identifier.urihttps://hdl.handle.net/11468/19049
dc.identifier.volume37en_US
dc.identifier.wosWOS:000337939900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalathionen_US
dc.subjectOrganophosphate Intoxicationen_US
dc.subjectOral Intralipid Emulsionen_US
dc.subjectPancreatic Beta-Cell Injuryen_US
dc.titleOral intralipid emulsion use: a novel therapeutic approach to pancreatic ?-cell injury caused by malathion toxicity in ratsen_US
dc.titleOral intralipid emulsion use: a novel therapeutic approach to pancreatic ?-cell injury caused by malathion toxicity in rats
dc.typeArticleen_US

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