The effects of erythropoietin on bacterial translocation and inflammation in rats with obstructive jaundice

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dc.contributor.authorOnder, Alin
dc.contributor.authorKapan, Murat
dc.contributor.authorYuksel, Hatice
dc.contributor.authorTekin, Recep
dc.contributor.authorKele, Ayserur
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorArikanoglu, Zulfu
dc.date.accessioned2024-04-24T17:38:23Z
dc.date.available2024-04-24T17:38:23Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractINTRODUCTION: Obstruction of the common bile duct is associated with hepatic paranchymal damage and increased susceptibility to subsequent bacterial infections. Erythropoietin has antiinflammatory and cytoprotective effects and it induces antiinflammatory cytokines and suppresses the production of proinflammatory cytokines. In this study, we aimed to investigate the effect of Erythropoietin on bacterial translocation, inflammation and tissue damage in rats with obstructive jaundice. MATERIALS AND METHODS: Thirty-two Wistar albino rats (200-250 g) were divided into 4 groups as follows: Group 1 (Sham); only hepatoduodenal ligament dissection, Group 2 (Erythropoietin); hepatoduodenal ligament dissection and given 500 IU/kg Erythropoietin subcutaneously, Group 3 (Obstructive jaundice); complete hepatoduodenal ligament ligation, Group 4 (Obstructive jaundice + Erythropoietin); complete hepatoduodenal ligament ligation and given 500 IU/kg Erythropoietin subcutaneously. After 7 days, the rats were sacrificed by taking blood from the heart for biochemical analyses. Peritoneal swab culture, liver, mesenteric lymph nodes, spleen and ileum were collected for microbiological and histopathological examinations. RESULTS: Erythropoietin reduced the secretion of inflammatory cytokines, oxidative damage and bacterial translocation, prevent the formation of inflammatory changes in intestine and liver after obstructive jaundice. Conclusion: The treatment of EPO in rats with Of reduces bacterial translocation, inflammation and tissue damage.en_US
dc.identifier.endpage165en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue2en_US
dc.identifier.pmid24901383
dc.identifier.scopus2-s2.0-84906224851
dc.identifier.scopusqualityQ3
dc.identifier.startpage159en_US
dc.identifier.urihttps://hdl.handle.net/11468/21428
dc.identifier.volume85en_US
dc.identifier.wosWOS:000217042100010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani Di Chirurgia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacterial Translocationen_US
dc.subjectErythropoietinen_US
dc.subjectInflammationen_US
dc.subjectObstructive Jaundiceen_US
dc.titleThe effects of erythropoietin on bacterial translocation and inflammation in rats with obstructive jaundiceen_US
dc.titleThe effects of erythropoietin on bacterial translocation and inflammation in rats with obstructive jaundice
dc.typeArticleen_US

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