Glutamine provides effective protection against deltamethrin-induced acute hepatotoxicity in rats but not against nephrotoxicity

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dc.contributor.authorGündüz, Ercan
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorİbiloğlu, İbrahim
dc.contributor.authorEkinci, Aysun
dc.contributor.authorDursun, Recep
dc.contributor.authorZengin, Yılmaz
dc.contributor.authorİçer, Mustafa
dc.contributor.authorUslukaya, Ömer
dc.contributor.authorEkinci, Cenap
dc.contributor.authorGüloğlu, Cahfer
dc.date.accessioned2024-04-24T17:56:36Z
dc.date.available2024-04-24T17:56:36Z
dc.date.issued2015
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Ana Bilim Dalı, Acil Tıp Ana Bilim Dalıen_US
dc.description.abstractBackground: The aim of this study was to investigate the protective effects of L-glutamine (GLN) against liver and kidney injury caused by acute toxicity of deltamethrin (DLM). Material/Methods: Thirty-two rats were indiscriminately separated into 4 groups with 8 rats each: control group (distilled water; 10 ml/kg, perorally[p.o.]), DLM group (35 mg/kg p.o. one dose.), GLN group (1.5 gr/kg, p.o. single dose.) and DLM (35 mg/kg p.o. one dose.) + GLN group (1.5 gr/kg, p.o. one dose after 4 hours.). Testing for total antioxidant status (TAS), total oxidant status (TOS), interleukin-1 beta (IL-1?), tumor necrosis factor-alpha (TNF-?), and interleukin-6 (IL-6) analyses were performed on tissue samples, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), urea, and creatinine were analyzed on serum samples. Liver and kidney samples were histopathologically analyzed. Results: The TOS level in liver was significantly higher in the DLM group than in the control group, and the level in DLM+GLN group was considerably lower than in the DLM group. The TAS level in the DLM+GLN group was considerably higher than in the control and DLM groups. The TAS level in kidney tissues was considerably lower in the DLM group than in controls, but was similar to other groups. Histopathological analyses of liver tissues established a significant difference between DLM and DLM+GLN groups in terms of grade 2 hepatic injury. However, no significant difference was found between DLM and DLM+GLN groups in terms of kidney injury. Conclusions: Glutamine leads to significant improvement in deltamethrin-induced acute hepatotoxicity in terms of histopathologic results, tissue oxidative stress parameters, and serum liver function marker enzymes.en_US
dc.identifier.citationGündüz, E., Ülger, B. V., İbiloğlu, İ., Ekinci, A., Dursun, R., Zengin, Y. ve diğerleri. (2015). Glutamine provides effective protection against deltamethrin-induced acute hepatotoxicity in rats but not against nephrotoxicity. Medical Science Monitor, 21, 1107-1114.
dc.identifier.doi10.12659/msm.893180
dc.identifier.endpage1114en_US
dc.identifier.issn1234-1010
dc.identifier.pmid25890620
dc.identifier.scopus2-s2.0-84928125473
dc.identifier.scopusqualityQ1
dc.identifier.startpage1107en_US
dc.identifier.urihttps://doi.org/10.12659/msm.893180
dc.identifier.urihttps://hdl.handle.net/11468/23590
dc.identifier.volume21en_US
dc.identifier.wosWoSIDEksik
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute kidney injuryen_US
dc.subjectDrug-induced liver injuryen_US
dc.subjectGlutamic aciden_US
dc.subjectOxidative stressen_US
dc.titleGlutamine provides effective protection against deltamethrin-induced acute hepatotoxicity in rats but not against nephrotoxicityen_US
dc.titleGlutamine provides effective protection against deltamethrin-induced acute hepatotoxicity in rats but not against nephrotoxicity
dc.typeArticleen_US

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