The effect of clomiphene citrate on oxidative stress parameters in polycystic ovarian syndrome

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dc.contributor.authorPeker, Nurullah
dc.contributor.authorTuran, Gokce
dc.contributor.authorEge, Serhat
dc.contributor.authorBademkiran, Muhammet Hanifi
dc.contributor.authorKaracor, Talip
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-04-24T16:24:27Z
dc.date.available2024-04-24T16:24:27Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to examine the possible association between the oxidative stress parameters and clomiphene citrate resistance in polycystic ovary syndrome. The demographic data, hormone profiles and oxidant and antioxidant values of 50 clomiphene citrate-resistant polycystic ovary syndrome patients (Group 1), 32 clomiphene citrate-sensitive polycystic ovary syndrome patients (Group 2) and 87 non-polycystic ovary syndrome patients (Group 3) were compared. The average age, follicle-stimulating hormone, oestradiol, thyroid-stimulating hormone and prolactin values of the three groups were found to be homogeneous. Ferroxidase, catalase and myeloperoxidase levels were determined to be lower in the clomiphene citrate-resistant group compared to clomiphene citrate-sensitive and non-polycystic ovary syndrome groups (p < .001). As a result, Polycystic ovary syndrome patients with clomiphene resistance had lower antioxidant (catalase and ferroxidase) levels compared to those who were sensitive to clomiphene and who did not have polycystic ovary syndrome. The myeloperoxidase levels also demonstrated the same trend, which might be due to a compensation mechanism.Impact Statement What is already known on this subject? In the literature, there are many studies evaluating the association between PCOS and oxidative stress. No research related to antioxidants in clomiphene citrate-sensitive and clomiphene citrate-resistant PCOS patients was found in the relevant literature. What do the results of this study add? In this study, the antioxidants catalase and ferroxidase were found to be lower in PCOS women compared to non-PCOS; however, they were the lowest in clomiphene citrate-resistant PCOS women. Interestingly, myeloperoxidase, which is a part of oxidative stress, was also found to be higher in the non-PCOS group.en_US
dc.description.sponsorshipTUBITAK [117S455]en_US
dc.description.sponsorshipThe blood samples in this study were studied with the support of TUBITAK project number 117S455.en_US
dc.identifier.doi10.1080/01443615.2020.1719052
dc.identifier.endpage117en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue1en_US
dc.identifier.pmid32131660
dc.identifier.scopus2-s2.0-85081274902
dc.identifier.scopusqualityQ3
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2020.1719052
dc.identifier.urihttps://hdl.handle.net/11468/16716
dc.identifier.volume41en_US
dc.identifier.wosWOS:000518563200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectOxidative Stressen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectClomiphene Citrateen_US
dc.titleThe effect of clomiphene citrate on oxidative stress parameters in polycystic ovarian syndromeen_US
dc.titleThe effect of clomiphene citrate on oxidative stress parameters in polycystic ovarian syndrome
dc.typeArticleen_US

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