Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia

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dc.contributor.authorSimsek, Seref
dc.contributor.authorYildirim, Veli
dc.contributor.authorCim, Abdullah
dc.contributor.authorKaya, Savas
dc.date.accessioned2024-04-24T17:08:00Z
dc.date.available2024-04-24T17:08:00Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this study, it was aimed to understand the underlying possible immunopathogenesis of first episode, early onset schizophrenia (EOS) through profiling the T helper 1 (Th-1) cell cytokines TNF-, IFN-, and IL-2, Th-2 cell cytokines IL-4 and IL-10, Th-17 cell cytokine IL-17A, and inflammatory cytokine IL-6. Methods: The study included a total of 30 children, admitted to child psychiatry outpatient clinic aged between 10 and 17 years of age, who had not received prior therapy and were diagnosed with psychosis according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) as the patient group, and 26 age- and gender-matched children as the control group. Structured psychiatric interviews (K-SADS-PL and PANSS) were conducted with all participants. The BD Cytokine Bead Array Human Th-1/Th-2/Th-17 Cytokine Kit is used for the measurement of serum cytokines, for example, IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-, and IFN-. Results: There was no significant difference between groups in terms of IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-, and IFN- levels (p>0.05). However, there was a significant correlation between IL-10 and IL-4 with negative symptoms of EOS (r=-0.65, p=0.02 and r=0.67, p=0.02, respectively). Conclusion: IL4 and IL-10 levels have a relationship with negative symptoms of disease. Therefore, this study might suggest that immunological processes might have a role in the disease pathophysiology.en_US
dc.identifier.doi10.1089/cap.2015.0220
dc.identifier.endpage726en_US
dc.identifier.issn1044-5463
dc.identifier.issn1557-8992
dc.identifier.issue8en_US
dc.identifier.pmid27384868
dc.identifier.scopus2-s2.0-84991615251
dc.identifier.scopusqualityQ2
dc.identifier.startpage721en_US
dc.identifier.urihttps://doi.org/10.1089/cap.2015.0220
dc.identifier.urihttps://hdl.handle.net/11468/17153
dc.identifier.volume26en_US
dc.identifier.wosWOS:000386136000008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Child and Adolescent Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEarly-Onset Schizophreniaen_US
dc.subjectFirst Episode Psychosisen_US
dc.subjectCytokineen_US
dc.subjectIl-17aen_US
dc.titleSerum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophreniaen_US
dc.titleSerum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia
dc.typeArticleen_US

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