The protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue

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dc.contributor.authorBakir, Salih
dc.contributor.authorYazgan, Umit Can
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorElbey, Bilal
dc.contributor.authorKizil, Murat
dc.contributor.authorKelle, Mustafa
dc.date.accessioned2024-04-24T17:20:32Z
dc.date.available2024-04-24T17:20:32Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The purpose of this study was to perform a histopathological investigation, at the light microscopy level, of the protective effects of pomegranate extract in cisplatin-induced liver and kidney damage in rats. Material and methods: Twenty-eight adult male Wistar albino rats were randomly divided into four groups of seven animals: Group 1: Control; Group 2: Treated for 10 consecutive days by gavage with pomegranate juice (2ml/kg/day); Group 3: Injected intraperitoneally with cisplatin (8mg/kg body weight, single dose) onset of the day 5, and Group 4: Treated by gavage with pomegranate juice 10 days before and after a single injection of cisplatin onset of the day 5. After 10 days, the animals were sacrificed and their kidneys and liver tissue samples were removed from each animal after experimental procedures. Cisplatin-induced renal and hepatic toxicity and the effect of pomegranate juice were evaluated by histopatological examinations. Results: In the kidney tissue, pomegranate juice significantly ameliorated cisplatin-induced structural alterations when compared with the cisplatin alone group. But in the liver tissue, although pomegranate juice attenuated the cisplatin-induced toxicity only in two rats, significant improvement was not observed. Conclusion: In conclusion, these results demonstrate that the anti-oxidant pomegranate juice might have a protective effect against cisplatin-induced toxicity in rat kidney, but not in liver. Pomegranate juice could be beneficial as a dietary supplement in patients receiving chemotherapy medications.en_US
dc.identifier.doi10.3109/13813455.2015.1068336
dc.identifier.endpage156en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue4en_US
dc.identifier.pmid26247305
dc.identifier.scopus2-s2.0-84945455579
dc.identifier.scopusqualityQ1
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.3109/13813455.2015.1068336
dc.identifier.urihttps://hdl.handle.net/11468/19114
dc.identifier.volume121en_US
dc.identifier.wosWOS:000365606800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatin Toxicityen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectPomegranate Extracten_US
dc.titleThe protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissueen_US
dc.titleThe protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue
dc.typeArticleen_US

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