An investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis

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dc.authorid0000-0003-3353-1871en_US
dc.authorid0000-0003-0199-453Xen_US
dc.contributor.authorKatanalp, Ömer Faruk
dc.contributor.authorKoçhan, Akın
dc.date.accessioned2024-03-26T13:26:30Z
dc.date.available2024-03-26T13:26:30Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study was to present allergens involved in the etiology of atopic dermatitis (AD) in dogs, to determine and classify the clinical severity of the disease using the CADESI-4 and pruritus scores, to investigate changes in serum cytokine levels in dogs with AD and their relationship with clinical findings, and to investigate the effects of oclacitinib maleate on clinical improvement and serum cytokine levels. The material of the study consisted of 20 dogs diagnosed with AD and 10 healthy dogs. CADESI and pVAS scores were obtained from the patients, and blood samples were taken. Hematological analyses, specific allergen tests (polycheck), and ELISA analyses were performed. Oclacitinib maleate (Apoquel, Zoetis) was administered orally to the patient dogs at a dose of 0.5 mg/kg twice a day for 7 days. It was found that the most common allergens involved in the etiology of AD in dogs were house dust mites type 1, house dust mites type 2, and mold fungi, and the mean CADESI and pVAS scores for clinical findings such as pruritus, alopecia, erythema, and lichenification in dogs with AD were 48 and 5.15 respectively. When compared to the control group, an increase in the percentage of eosinophils (p < 0.05) and a decrease in serum IL-2 and IL-4 levels (p < 0.05) were detected. When compared to other groups, it was found that the mean serum IL-4 levels (p < 0.05) were low and IL-13 levels (p < 0.05) were high in the group with severe clinical findings. It was determined that the use of oclacitinib maleate resulted in clinical improvement and caused an increase in the mean serum IL-2 levels (p < 0.05) and a decrease in IL-31 and IL-33 levels (p < 0.05). Oclacitinib maleate (Apoquel, Zoetis) was found to be an effective and reliable drug that can be used in the treatment of the disease, but it was concluded that the duration of use should be extended.en_US
dc.identifier.citationKatanalp, Ö. F. ve Koçhan, A. (2023). An investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis. Medycyna Weterynaryjna, 80(1), 30-37.en_US
dc.identifier.doi10.21521/mw.6828
dc.identifier.endpage37en_US
dc.identifier.issn0025-8628
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85181109377
dc.identifier.scopusqualityQ4
dc.identifier.startpage30en_US
dc.identifier.urihttp://www.medycynawet.edu.pl/images/stories/pdf/pdf2023/00-artwait/2024016828.pdf
dc.identifier.urihttps://hdl.handle.net/11468/13741
dc.identifier.volume80en_US
dc.identifier.wosWOS:001168256700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKatanalp, Ömer Faruk
dc.institutionauthorKoçhan, Akın
dc.language.isoenen_US
dc.publisherPolskie Towarzystwo Nauk Weterynaryjnychen_US
dc.relation.ispartofMedycyna Weterynaryjna
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtopic dermatitisen_US
dc.subjectCytokinesen_US
dc.subjectDogen_US
dc.subjectOclacitinib maleateen_US
dc.titleAn investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitisen_US
dc.titleAn investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis
dc.typeArticleen_US

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