Increased expression of E-cadherin, endothelin-1, and CD68 in preeclamptic placentas

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dc.contributor.authorİrtegün, Sevgi
dc.contributor.authorTekin, Mehmet Ali
dc.contributor.authorAlpaycı, Rojbin
dc.date.accessioned2024-04-24T17:27:27Z
dc.date.available2024-04-24T17:27:27Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Preeclampsia (PE) is a complex pregnancy-specific disorder characterized by the onset of hypertension and proteinuria in the second trimester of pregnancy. The pathogenesis of PE still remains unknown. Revealing the specific proteins involved in placental functions is important for a better understanding of the pathogenesis of PE. In this study, we aimed to investigate the expression levels of E-cadherin, endothelin-1, and CD68 in both preeclamptic and normal placentas. Materials and Methods: In this study, placentas after birth at 35-38 weeks were included. Ten preeclamptic placentas and 10 normal placentas were used. The expression levels of E-cadherin, endothelin-1, and CD68 were measured by western blot. Results: It was observed that the expression of E-cadherin and endothelin-1 was not at detectable levels in normal placentas; however, E-cadherin and endothelin-1 were observed to be highly expressed in preeclamptic placentas. In addition, the expression of CD68 was found to be markedly increased in preeclamptic placentas in comparison to control placentas. Conclusion: The increased expression of E-cadherin, endothelin-1, and CD68 may play an important role in impaired trophoblast invasion, endothelial dysfunction, and inadequate spiral remodeling, which are key factors involved in the pathogenesis of PE.en_US
dc.identifier.citationİrtegün, S., Tekin, M. A. ve Alpaycı, R. (2016). Increased expression of E-cadherin, endothelin-1, and CD68 in preeclamptic placentas. Erciyes Tip Dergisi, 38(4), 149-152.
dc.identifier.doi10.5152/etd.2016.0090
dc.identifier.endpage152en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue4en_US
dc.identifier.startpage149en_US
dc.identifier.trdizinid212597
dc.identifier.urihttps://doi.org/10.5152/etd.2016.0090
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/212597
dc.identifier.urihttps://hdl.handle.net/11468/19942
dc.identifier.volume38en_US
dc.identifier.wosWOS:000390949600005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectE-Cadherinen_US
dc.subjectEndothelin-1en_US
dc.subjectCd68en_US
dc.subjectPlacentaen_US
dc.titleIncreased expression of E-cadherin, endothelin-1, and CD68 in preeclamptic placentasen_US
dc.titleIncreased expression of E-cadherin, endothelin-1, and CD68 in preeclamptic placentas
dc.typeArticleen_US

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