Time-dependent oxidative stress effects of percutaneous nephrolithotomy

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dc.contributor.authorSoylemez, Haluk
dc.contributor.authorBozkurt, Yasar
dc.contributor.authorPenbegül, Necmettin
dc.contributor.authorSancaktutar, Ahmet Ali
dc.contributor.authorAltunoluk, Bulent
dc.contributor.authorAtar, Murat
dc.contributor.authorEvliyaoglu, Osman
dc.date.accessioned2024-04-24T15:59:52Z
dc.date.available2024-04-24T15:59:52Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim of this study was to investigate the effects of operation time of percutaneous nephrolithotomy (PCNL) on renal function and hemodynamic response. Thirty-four patients (14 male, 20 female) with normal renal function who underwent unilateral single-tract PCNL between December 2010 and June 2011 were included in the study. The age, sex, stone size, grade of hydronephrosis, operative time, access pole, shock number of lithotripter, complications, stone-free rate, and hemodynamic parameters during operation were recorded. Total blood count and oxidative stress parameters such as paraoxonase 1 (PON1), total antioxidant status (TAS), total oxidant status (TOS), and malonyldialdehyde (MDA) levels were examined before the operation as baseline levels and then at 30, 60, 90, and 120 min during the operation. The mean age of the patients was 31.4 +/- 18.8 (9-66 years) years. Mean stone size was 35.5 +/- 15.6 mm. Mean serum BUN and creatinine did not change postoperatively (p > 0.05), whereas mean WBC and 24-h urine cortisol were positively and hematocrite were negatively changed significantly (p < 0.05). Oxidative stress parameters such as PON1 and TAS showed statistically significant decreases, while TOS and MDA showed statistically significant increases with increased operation time, especially after 1 h (p < 0.005). A bivariate correlation test showed correlation between oxidative stress parameters and operation time (p = 0.002), but no correlation was found between oxidative stress parameters and other parameters (p > 0.05). Oxidative stress and response to it increased with increasing operative time during a PCNL procedure, especially after 1 h. Further studies with a larger and longer series should be performed to clarify this issue further.en_US
dc.identifier.doi10.1007/s00240-012-0532-9
dc.identifier.endpage71en_US
dc.identifier.issn2194-7228
dc.identifier.issue1en_US
dc.identifier.pmid23532426
dc.identifier.scopus2-s2.0-84880923884
dc.identifier.scopusqualityQ2
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-012-0532-9
dc.identifier.urihttps://hdl.handle.net/11468/14291
dc.identifier.volume41en_US
dc.identifier.wosWOS:000318336000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrolithiasis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOperative Timeen_US
dc.subjectPercutaneous Nephrolithotomyen_US
dc.subjectOxidative Stressen_US
dc.titleTime-dependent oxidative stress effects of percutaneous nephrolithotomyen_US
dc.titleTime-dependent oxidative stress effects of percutaneous nephrolithotomy
dc.typeArticleen_US

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