Elevated amniotic fluid amino acid levels in fetuses with gastroschisis

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dc.contributor.authorKale, A.
dc.contributor.authorKale, E.
dc.contributor.authorAkdeniz, N.
dc.contributor.authorCanoruc, N.
dc.date.accessioned2024-04-24T17:18:09Z
dc.date.available2024-04-24T17:18:09Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractOur objective was to measure maternal plasma and amniotic fluid amino acid concentrations in pregnant women diagnosed as having fetuses with gastroschisis in the second trimester of pregnancy. Twenty-one pregnant women who had fetuses with gastroschisis detected by ultrasonography (gastroschisis group) in the second trimester and 32 women who had abnormal triple screenings indicating an increased risk for Down syndrome but had healthy fetuses (control group) were enrolled in the study. Amniotic fluid was obtained by amniocentesis, and maternal plasma samples were taken simultaneously. The chromosomal analysis of the study and control groups was normal. Levels of free amino acids and non-essential amino acids were measured in plasma and amniotic fluid samples using EZ:fast kits (EZ:fast GC/FID free (physiological) amino acid kit) by gas chromatography (Focus GC AI 3000 Thermo Finnigan analyzer). The mean levels of essential amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine) and non-essential amino acids (alanine, glycine, proline, and tyrosine) in amniotic fluid were found to be significantly higher in fetuses with gastroschisis than in the control group (P < 0.05). A significant positive correlation between maternal plasma and amniotic fluid concentrations of essential and nonessential amino acids was found only in the gastroschisis group (P < 0.05). The detection of significantly higher amino acid concentrations in the amniotic fluid of fetuses with a gastroschisis defect than in healthy fetuses suggests the occurrence of amino acid malabsorption or of amino acid leakage from the fetus into amniotic fluid.en_US
dc.identifier.doi10.1590/S0100-879X2006000800004
dc.identifier.endpage1025en_US
dc.identifier.issn0100-879X
dc.identifier.issue8en_US
dc.identifier.pmid16906276
dc.identifier.scopus2-s2.0-33747344678
dc.identifier.scopusqualityQ1
dc.identifier.startpage1021en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2006000800004
dc.identifier.urihttps://hdl.handle.net/11468/18639
dc.identifier.volume39en_US
dc.identifier.wosWOS:000239936900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmino Acidsen_US
dc.subjectGastroschisisen_US
dc.subjectAmniotic Fluiden_US
dc.titleElevated amniotic fluid amino acid levels in fetuses with gastroschisisen_US
dc.titleElevated amniotic fluid amino acid levels in fetuses with gastroschisis
dc.typeArticleen_US

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