Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-? Production in PBMC of Patients with Behcet's Disease

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dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorPektanc, Gulsum
dc.contributor.authorAkkurt, Zeynep M.
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorTurkcu, Fatih M.
dc.contributor.authorKalkanli-Tas, Sevgi
dc.date.accessioned2024-04-24T17:12:16Z
dc.date.available2024-04-24T17:12:16Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBehcet's disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-alpha production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [213S016]en_US
dc.description.sponsorshipThis work was supported by Grant 213S016 from the Scientific and Technological Research Council of Turkey. The authors thank Kadir Demircan for critical reading of the paper.en_US
dc.identifier.doi10.1155/2016/5414369
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.pmid27445436
dc.identifier.scopus2-s2.0-84982786811
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2016/5414369
dc.identifier.urihttps://hdl.handle.net/11468/17911
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000379441900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofMediators of Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titlePharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-? Production in PBMC of Patients with Behcet's Diseaseen_US
dc.titlePharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-? Production in PBMC of Patients with Behcet's Disease
dc.typeArticleen_US

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