Functional roles of angiogenic factors and receptors on non-endothelial cells in the oropharyngeal cavity of the chukar partridge (Alectoris chukar)

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dc.contributor.authorSagsoz, Hakan
dc.contributor.authorSaruhan, Berna G.
dc.contributor.authorErdogan, Serkan
dc.date.accessioned2024-04-24T17:11:25Z
dc.date.available2024-04-24T17:11:25Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe vascular endothelial growth factor (VEGF) family belong to the platelet-derived growth factor supergene family and is involved in angiogenesis and mitogenesis. The VEGF-VEGFR system regulates endothelial cell proliferation, migration, vascular permeability, secretion and other non-endothelial cells functions. To clarify the possible role of endothelial and non-endothelial cells, VEGF and its receptors, vascular endothelial cell growth inhibitor (VEGI) were immunohistochemically examined in oropharyngeal organs. Ten adult partridges were used in this study and the pharynx and larynx were dissected together with the palate and tongue. VEGI, VEGF and its receptor were highly expressed in luminal epithelial and stromal cells, when compared to glandular epithelial and muscle cells (P<0.05). Moreover, VEGF, its receptors and VEGI were expressed rather strongly in the endothelial cells of the blood capillaries and in both the endothelial and smooth muscle cells of the large and small blood vessels. In conclusion, VEGF and its receptors (flt1/fms, flk1/KDR and flt4) and VEGI were expressed by various cell groups at varying intensity in the oropharyngeal organs. This demonstrates that they play a critical role in the regulation and maintenance of the functions in cells different from endothelial ones as well as in cell proliferation, differentiation, apoptosis and angiogenesis.en_US
dc.identifier.doi10.1111/azo.12149
dc.identifier.endpage55en_US
dc.identifier.issn0001-7272
dc.identifier.issn1463-6395
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84949516379
dc.identifier.scopusqualityQ2
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.1111/azo.12149
dc.identifier.urihttps://hdl.handle.net/11468/17502
dc.identifier.volume98en_US
dc.identifier.wosWOS:000392846400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Zoologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBirden_US
dc.subjectImmunohistochemistryen_US
dc.subjectPalateen_US
dc.subjectTongueen_US
dc.subjectVegf-Vegfr Systemen_US
dc.titleFunctional roles of angiogenic factors and receptors on non-endothelial cells in the oropharyngeal cavity of the chukar partridge (Alectoris chukar)en_US
dc.titleFunctional roles of angiogenic factors and receptors on non-endothelial cells in the oropharyngeal cavity of the chukar partridge (Alectoris chukar)
dc.typeArticleen_US

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