Functional roles of angiogenic factors and receptors on non-endothelial cells in the oropharyngeal cavity of the chukar partridge (Alectoris chukar)
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The vascular endothelial growth factor (VEGF) family belong to the platelet-derived growth factor supergene family and is involved in angiogenesis and mitogenesis. The VEGF-VEGFR system regulates endothelial cell proliferation, migration, vascular permeability, secretion and other non-endothelial cells functions. To clarify the possible role of endothelial and non-endothelial cells, VEGF and its receptors, vascular endothelial cell growth inhibitor (VEGI) were immunohistochemically examined in oropharyngeal organs. Ten adult partridges were used in this study and the pharynx and larynx were dissected together with the palate and tongue. VEGI, VEGF and its receptor were highly expressed in luminal epithelial and stromal cells, when compared to glandular epithelial and muscle cells (P<0.05). Moreover, VEGF, its receptors and VEGI were expressed rather strongly in the endothelial cells of the blood capillaries and in both the endothelial and smooth muscle cells of the large and small blood vessels. In conclusion, VEGF and its receptors (flt1/fms, flk1/KDR and flt4) and VEGI were expressed by various cell groups at varying intensity in the oropharyngeal organs. This demonstrates that they play a critical role in the regulation and maintenance of the functions in cells different from endothelial ones as well as in cell proliferation, differentiation, apoptosis and angiogenesis.
Açıklama
Anahtar Kelimeler
Bird, Immunohistochemistry, Palate, Tongue, Vegf-Vegfr System
Kaynak
Acta Zoologica
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
98
Sayı
1
