Effect of ovariectomy and female sex hormones administration upon gastric ulceration induced by cold and immobility restraint stress

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dc.contributor.authorKurt, Dogan
dc.contributor.authorSaruhan, Berna G.
dc.contributor.authorKanay, Zeki
dc.contributor.authorYokus, Beran
dc.contributor.authorKanay, Berna E.
dc.contributor.authorUnver, Ozkan
dc.contributor.authorHatipoglu, Savas
dc.date.accessioned2024-04-24T17:33:36Z
dc.date.available2024-04-24T17:33:36Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the protective effects of estrogen and progesterone administrations on gastric mucosal barrier of rats applied ovariectomy, cold and immobility stress. Methods: Seventy female Wistar rats, obtained from Medical Science Application and Research Center, Dicle University, Turkey on the year 2004, were divided into 10 separate groups (n=7). Nothing was applied to the animals of Group 1 (control); bilateral ovariectomy was performed on the animals of the Groups 2, 4, 5, 6, 7, 8, 9, and 10. Groups 5 and 6 was applied 5 mg/kg 17beta-estradiol and groups 7 and 8 was applied 10 mg/kg progesterone for 7 days. The animals in the Groups 9 and 10 were applied 2.5 mg/kg 17beta-estradiol and 5 mg/g progesterone during 7 days. The animals in the groups 3, 4, 6, 8 and 1 were exposed to cold and immobility stress for 4 hours at 4 degrees C. Results: The levels of mucus and phospholipids were decreased in the rats applied ovariectomy and stress as compared to the control groups (p<0.001). The increase determined the mucus and phospholipids levels in estrogen and progesterone administered rats as compared to stress applied group (p<0.001). While the cold and immobility stress causes important damages in gastric mucosa, estrogen and progesterone administrations has protective effects in ovariectomized rats. Conclusion: The estrogen and progesterone administration prevents the stress that caused decrease in the levels of mucus and phospholipids, thus females are more resistant to gastric ulcer rather than males due to their sex hormones.en_US
dc.identifier.endpage1027en_US
dc.identifier.issn0379-5284
dc.identifier.issue7en_US
dc.identifier.pmid17603703
dc.identifier.scopus2-s2.0-34548380320
dc.identifier.scopusqualityQ2
dc.identifier.startpage1021en_US
dc.identifier.urihttps://hdl.handle.net/11468/20763
dc.identifier.volume28en_US
dc.identifier.wosWOS:000248396500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffect of ovariectomy and female sex hormones administration upon gastric ulceration induced by cold and immobility restraint stressen_US
dc.titleEffect of ovariectomy and female sex hormones administration upon gastric ulceration induced by cold and immobility restraint stress
dc.typeArticleen_US

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