The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion

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dc.authorid0000-0002-7451-2786en_US
dc.authorid0000-0003-3878-988Xen_US
dc.authorid0000-0001-7336-871Xen_US
dc.authorid0000-0001-5708-3431en_US
dc.authorid0000-0002-7931-2941en_US
dc.authorid0000-0003-0882-0524en_US
dc.contributor.authorDüzköprü, Yakup
dc.contributor.authorOruç, Zeynep
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorÜlkü, Refik
dc.contributor.authorTanrıkulu, Çetin
dc.contributor.authorEsmer, Derya
dc.contributor.authorBırak, Ali
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2023-11-30T06:08:58Z
dc.date.available2023-11-30T06:08:58Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractAim of the study: Vascular endothelial growth factor (VEGF) is one of the parameters that has been studied in differential diagnosis of malignant fluids. This study is aimed at evaluate applicability of serum, fluid VEGF level and fluid to serum VEGF ratio in the diagnosis of malignant pleural mesothelioma (MPM). Material and methods: The patients with pleural effusion over age of 18, between 2011 and 2015 were included in the study. They were divided into three groups: Group 1 - mesothelioma patients; group 2 - other malignancies; and group 3 - benign aetiologies. Group 1 and 2 were termed as the malignant group. Fluid, serum VEGF levels, and the ratio of fluid/serum VEGF level were studied to evaluate the fluid/ serum VEGF ratio in all groups. Results: Twenty cases with mesothelioma, 44 cases with other malignancies, and 20 cases with benign aetiologies were included in this study. No statistically significant difference was found according to serum VEGF levels for all groups, (group 1: 437 ±324 pg/ ml, group 2: 354 ±223 pg/ml, group 3: 373 ±217 pg/ml, p = 0.836), while fluid VEGF levels showed a statistically significant difference (group 1: 3359 ±700 pg/ml, group 2: 2175 ±435 pg/ml, group 3: 1092 ±435 pg/ml, p = 0.041). The ratio of fluid to serum VEGF levels showed a difference, at the significance limit, between the malignant (group 1 and group 2) and benign (group 3) groups (8.83 ±1.29 vs. 4.57 ±1.07, p = 0.059) but showed a statistically significant difference between the mesothelioma and benign groups (12.11 ±1.68 vs. 4.57 ±1.07, p = 0.044). Conclusions: The VEGF fluid/serum ratio may be an applicable parameter in the differential diagnosis of malignant fluids, especially MPM.en_US
dc.identifier.citationDüzköprü, Y., Oruç, Z., Kaplan, M. A., Ülkü, R., Tanrıkulu, Ç., Esmer, D. ve diğerleri. (2017). The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion. Wspolczesna Onkologia, 21(3), 213-217.en_US
dc.identifier.doi10.5114/wo.2017.70111
dc.identifier.endpage217en_US
dc.identifier.issn1428-2526
dc.identifier.issue3en_US
dc.identifier.pmid29180928
dc.identifier.scopus2-s2.0-85033776711
dc.identifier.scopusqualityQ2
dc.identifier.startpage213en_US
dc.identifier.urifile:///C:/Users/Rojbin/Downloads/WO_Art_30592-10.pdf
dc.identifier.urihttps://hdl.handle.net/11468/13064
dc.identifier.volume21en_US
dc.identifier.wosWOS:000416082900005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDüzköprü, Yakup
dc.institutionauthorOruç, Zeynep
dc.institutionauthorKaplan, Muhammet Ali
dc.institutionauthorEsmer, Derya
dc.institutionauthorÜlkü, Refik
dc.institutionauthorTanrıkulu, Çetin
dc.institutionauthorBırak, Ali
dc.institutionauthorKüçüköner, Mehmet
dc.institutionauthorUrakçı, Zuhat
dc.institutionauthorIşıkdoğan, Abdurrahman
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofWspolczesna Onkologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalignant mesotheliomaen_US
dc.subjectPleural effusionen_US
dc.subjectPleural fluid/ serum VEGF ratioen_US
dc.subjectVascular endothelial growth factor (VEGF)en_US
dc.titleThe importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusionen_US
dc.titleThe importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion
dc.typeArticleen_US

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