Flask and reactor scale production of plant growth regulators by Inonotus hispidus: optimization, immobilization and kinetic parameters

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dc.contributor.authorDogan, Bilal
dc.contributor.authorYildiz, Zeki
dc.contributor.authorAksoz, Nilufer
dc.contributor.authorEninanc, Ayse Betul
dc.contributor.authorDag, Ilknur
dc.contributor.authorYildiz, Abdunnasir
dc.contributor.authorDogan, Hasan Huseyin
dc.date.accessioned2024-04-24T16:24:57Z
dc.date.available2024-04-24T16:24:57Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aims of the presented study are to compare submerged, static, and solid-state fermentation in the production of gibberellic acid (GA(3)), indole acetic acid (IAA), and abscisic acid (ABA) by Inonotus hispidus, to optimize with a statistical approach, and to determine the kinetic parameters under flask and reactor conditions. The maximum concentrations of GA(3), (2478.85 & PLUSMN; 68.53 mg/L), ABA, (273.26 & PLUSMN; 6.17 mg/L) and IAA (30.67 & PLUSMN; 0.19 mg/L) were obtained in submerged conditions. After optimization, these values reached 2998.85 & PLUSMN; 28.85, 339.47 & PLUSMN; 5.50, and 34.56 & PLUSMN; 0.25 mg/L, respectively. Immobilization of fungal cells on synthetic fiber, polyurethane foam, and alginate beads resulted in an increase in plant growth regulators (PGR) production by 5.53%- 5.79% under optimized conditions. At the reactor scale, a significant increase was observed for GA(3) concentration, 5441.54 mg/L, which was 2.14 and 1.45 times higher than non-optimized and optimized conditions in the flask scale, respectively. The maximum values for ABA and IAA were 390.39 and 44.79 mg/L, respectively. Although the specific growth rate (& mu;) decreases relatively from non-optimized flask conditions to optimized reactor conditions, it was observed that the PGR amounts produced per liter medium (r(p)) and per gram biomass (Q(p)) increased significantly. This is the first report on the synthesis of PGR by Inonotus hispidus which could be crucial for sustainable agriculture.en_US
dc.description.sponsorshipScientific and Technological Research Council of Tuuml;rkiye (TUBITAK) [112T061]en_US
dc.description.sponsorshipThis work was supported by a grant (112T061) from The Scientific and Technological Research Council of Turkiye (TUBITAK).en_US
dc.identifier.doi10.1080/10826068.2023.2185636
dc.identifier.endpage1223en_US
dc.identifier.issn1082-6068
dc.identifier.issn1532-2297
dc.identifier.issue10en_US
dc.identifier.pmid37405401
dc.identifier.scopus2-s2.0-85164480079
dc.identifier.scopusqualityQ2
dc.identifier.startpage1210en_US
dc.identifier.urihttps://doi.org/10.1080/10826068.2023.2185636
dc.identifier.urihttps://hdl.handle.net/11468/16910
dc.identifier.volume53en_US
dc.identifier.wosWOS:001019827000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPreparative Biochemistry & Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbscisic Aciden_US
dc.subjectGibberellic Aciden_US
dc.subjectIndole Acetic Aciden_US
dc.subjectInonotus Hispidusen_US
dc.subjectOptimizationen_US
dc.titleFlask and reactor scale production of plant growth regulators by Inonotus hispidus: optimization, immobilization and kinetic parametersen_US
dc.titleFlask and reactor scale production of plant growth regulators by Inonotus hispidus: optimization, immobilization and kinetic parameters
dc.typeArticleen_US

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