Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode

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dc.contributor.authorAslan, Mehmet
dc.contributor.authorAydın, Fırat
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2024-04-24T16:10:38Z
dc.date.available2024-04-24T16:10:38Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectivesNivolumab is used in a treatment called immunotherapy, which helps the immune system cells to attack cancer cells. The electrochemical properties and quantification of this drug were performed using single-use pencil tips.Evidence acquisitionHere, a selective voltammetric method for the determination and electrochemical characterization of Nivolumab used in cancer therapy was developed for the first time using a disposable pencil electrode by cyclic voltammetry and differential pulse voltammetry techniques. Nivolumab exhibited an anodic signal at +0.879 V (vs. Ag/AgCl) in PBS (pH 3.0, 0.02 M NaCl) medium.ResultsThis procedure showed a linear response in phosphate buffer solutions (pH 3.0, 0.02 M NaCl) media within the concentration range of 0.01 mg mL-1 to 0.07 mg mL-1 and limit of detection and the limit of quantification values were determined to be 2.49 mu g mL-1 and 8.30 mu g mL-1, respectively.ConclusionsThe developed method offers an important analytical approach for the detection and characterization of NIVO. Precisely measuring and monitoring the levels of such drugs in real sample analyses or biological samples is critical for evaluating response to treatment, optimizing treatment strategies. Therefore, the method was applied to real sample analyses. Voltammetric results developed using PG electrode were compared with UV-Vis results. It has been determined that the results obtained are compatible with each other.en_US
dc.description.sponsorshipThis study was supported by Dicle University Scientific Research and Projects Board (DUBAP) with Project No: FB-21012. It was carried out within the scope of PhD thesis numbered 10512029. [FB-21012, 10512029]; Dicle University Scientific Research and Projects Board (DUBAP)en_US
dc.description.sponsorshipThis study was supported by Dicle University Scientific Research and Projects Board (DUBAP) with Project No: FB-21012. It was carried out within the scope of PhD thesis numbered 10512029.en_US
dc.identifier.citationAslan, M., Aydın, F. ve Levent, A. (2023). Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode. DARU, Journal of Pharmaceutical Sciences, 1-12.
dc.identifier.doi10.1007/s40199-023-00491-x
dc.identifier.issn2008-2231
dc.identifier.pmid37989824
dc.identifier.scopus2-s2.0-85177426439
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s40199-023-00491-x
dc.identifier.urihttps://hdl.handle.net/11468/14990
dc.identifier.wosWOS:001105128200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofDaru-Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectNivolumaben_US
dc.subjectVoltammetryen_US
dc.subjectPgeen_US
dc.titleElectrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrodeen_US
dc.titleElectrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
dc.typeArticleen_US

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