Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester (CAPE) on Hepatotoxicity and Pancreatic Injury Caused by Dichlorvos in Rats

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dc.contributor.authorAlp, Harun
dc.contributor.authorPinar, Neslihan
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorSahan, Mustafa
dc.contributor.authorOruc, Cem
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorSenol, Serkan
dc.date.accessioned2024-04-24T16:02:06Z
dc.date.available2024-04-24T16:02:06Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study was aimed to the investigate the protective effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity and pancreatic injury caused by acute dichlorvos (D) intoxication in rats. Forty-eight Wistar rats were randomly divided into seven groups each containing seven rats except control groups. The groups included control, D, CAPE, IL, D + CAPE, D + IL, and D + CAPE + IL. Total antioxidant status and total oxidative stress levels were measured by automated colorimetric assay. Tissues were evaluated using hematoxylin and eosin (H&E) staining. Tissues were analyzed with hematoxylin and eosin by using standard protocols. Also, Bcl-2, Bax and caspase-3 were evaluated by immunohistochemical method in liver tissue. Total oxidant status in control, CAPE, and IL groups were significantly lower, and total antioxidant status in the D + CAPE, D + IL, and D + IL + CAPE groups were significantly higher compared to the D group. CAPE and IL treatment decreased the apoptotic and mitotic cell count in liver tissue. Parenchymal necrosis caused by dichlorvos is observed in pancreas tissues of rats. Mild congestion and edema formation occurred in pancreas tissues following D + CAPE and D + IL therapies. These results indicate that CAPE and IL have the potential to decrease oxidative stress and hepatic and pancreatic injuries caused by acute dichlorvos intoxication. These drugs can be considered as a new method for supportive and protective therapy against pesticide intoxication.en_US
dc.identifier.doi10.1007/s10528-016-9757-6
dc.identifier.endpage815en_US
dc.identifier.issn0006-2928
dc.identifier.issn1573-4927
dc.identifier.issue6en_US
dc.identifier.pmid27365043
dc.identifier.scopus2-s2.0-84976472156
dc.identifier.scopusqualityQ2
dc.identifier.startpage803en_US
dc.identifier.urihttps://doi.org/10.1007/s10528-016-9757-6
dc.identifier.urihttps://hdl.handle.net/11468/14627
dc.identifier.volume54en_US
dc.identifier.wosWOS:000387577500004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofBiochemical Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrganophosphate Pesticideen_US
dc.subjectDichlorvosen_US
dc.subjectCapeen_US
dc.subjectIntralipiden_US
dc.subjectHepatotoxicityen_US
dc.subjectPancreatic Injuryen_US
dc.subjectOxidative Stressen_US
dc.titleProtective Effects of Intralipid and Caffeic Acid Phenethyl Ester (CAPE) on Hepatotoxicity and Pancreatic Injury Caused by Dichlorvos in Ratsen_US
dc.titleProtective Effects of Intralipid and Caffeic Acid Phenethyl Ester (CAPE) on Hepatotoxicity and Pancreatic Injury Caused by Dichlorvos in Rats
dc.typeArticleen_US

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