Effects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled study

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dc.contributor.authorSoylemez, Haluk
dc.contributor.authorKilic, Suleyman
dc.contributor.authorAtar, Murat
dc.contributor.authorPenbegül, Necmettin
dc.contributor.authorSancaktutar, Ahmet Ali
dc.contributor.authorBozkurt, Yasar
dc.date.accessioned2024-04-24T16:02:25Z
dc.date.available2024-04-24T16:02:25Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim Aim of this study is to evaluate the effects of micronised purified flavonoid fraction (Daflon (R)) on pain, semen analysis and color Doppler parameters in patients with painful varicocele. Materials and methods Forty varicocele patients whom have normal sperm concentration (>20 million/ml) were involved in the study. The patients were divided into two groups such as Daflon (n = 20) and placebo (n = 20) group. Pain score, semen analyses and Doppler sonography were performed in all patients before and after the treatment. Results In the first group, mean pain scores at 1, 3, 6 and 12 months were 1.80 +/- 1.32, 1.15 +/- 0.93, 1.05 +/- 0.95 and 0.95 +/- 0.89, respectively, all were significantly lower (P < 0.001 for each) than baseline (5.25 +/- 1.07). While semen volume, total sperm count, sperm concentration and morphology were not changed significantly, the motility of sperm increased significantly (P = 0.015) due to decrease in grade 1 sperms at the 6th month in the first group. Reflux time of left spermatic vein during the Valsalva maneuver decreased significantly (P < 0.001). Conclusions Results of this study suggest the safety and efficacy of Daflon in the treatment of varicocele-associated pain. However, these results of the present study must be confirmed by randomized placebo-controlled studies by using different drug doses and durations before making any recommendation for the use of Daflon.en_US
dc.identifier.doi10.1007/s11255-011-0038-3
dc.identifier.endpage408en_US
dc.identifier.issn0301-1623
dc.identifier.issue2en_US
dc.identifier.pmid21805085
dc.identifier.scopus2-s2.0-84863092018
dc.identifier.scopusqualityQ2
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-011-0038-3
dc.identifier.urihttps://hdl.handle.net/11468/14784
dc.identifier.volume44en_US
dc.identifier.wosWOS:000304403500011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConservative Treatmenten_US
dc.subjectMicronised Purified Flavonoid Fractionen_US
dc.subjectPainen_US
dc.subjectSemen Analysisen_US
dc.subjectVaricoceleen_US
dc.titleEffects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled studyen_US
dc.titleEffects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled study
dc.typeArticleen_US

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