Effects of Intrathecal Caffeic Acid Phenethyl Ester and Methylprednisolone on Oxidant/Antioxidant Status in Traumatic Spinal Cord Injuries

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dc.contributor.authorGocmez, Cuneyt
dc.contributor.authorCelik, Feyzi
dc.contributor.authorKamasak, Kagan
dc.contributor.authorKaplan, Metin
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorEvliyaoglu, Osman
dc.date.accessioned2024-04-24T16:24:09Z
dc.date.available2024-04-24T16:24:09Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurposeTo examine the effect of intrathecally given caffeic acid phenethyl ester (CAPE) on peroxidation and total oxidant and antioxidant systems, and the effect of intrathecally given methylprednisolone (MP) in spinal cord injury (SCI) models. Materials and MethodsFour groups of 10 rats were formed: (1) Laminectomy, intrathecal saline injection, no SCI (sham: S); (2) Laminectomy, intrathecal saline injection, SCI (control: SCI); (3) Laminectomy, intrathecally given single dose of 3 mg/kg MP, SCISCI (SCI+MP). 4) Laminectomy, intrathecally given single dose of 1 mu g/kg CAPE, SCI (SCI+CAPE). Malondialdehyde (MDA), total oxidant activity (TOA), total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) values in the spinal cord tissue were evaluated. ResultsWhen group S and group SCI were compared, MDA, TOA, and SOD parameters increased post-SCI (p<0.01). When compared with group SCI, it was observed that CAPE and MP decreased the MDA, TOA, and SOD levels (p<0.01). This decrease was more pronounced in the SCI+CAPE group. When group S and group SCI were compared, a statistically substantial decrease was observed in the post-SCI TAC levels. When compared with group SCI, it was shown that CAPE and MP treatment substantially increased TAC levels (p<0.001). ConclusionIntrathecal injection of both CAPE and MP inhibits lipid peroxidation and increase of oxidants in SCIs.en_US
dc.identifier.doi10.1055/s-0034-1371513
dc.identifier.endpage24en_US
dc.identifier.issn2193-6315
dc.identifier.issn2193-6323
dc.identifier.issue1en_US
dc.identifier.pmid24871822
dc.identifier.scopus2-s2.0-84901084952
dc.identifier.scopusqualityQ2
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1055/s-0034-1371513
dc.identifier.urihttps://hdl.handle.net/11468/16532
dc.identifier.volume76en_US
dc.identifier.wosWOS:000348916900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofJournal of Neurological Surgery Part A-Central European Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectLipid Peroxidationen_US
dc.subjectIntrathecalen_US
dc.titleEffects of Intrathecal Caffeic Acid Phenethyl Ester and Methylprednisolone on Oxidant/Antioxidant Status in Traumatic Spinal Cord Injuriesen_US
dc.titleEffects of Intrathecal Caffeic Acid Phenethyl Ester and Methylprednisolone on Oxidant/Antioxidant Status in Traumatic Spinal Cord Injuries
dc.typeArticleen_US

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