Serum total and high-density lipoprotein phospholipids: Independent predictive value for cardiometabolic risk

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dc.contributor.authorOnat, Altan
dc.contributor.authorCakmak, H. Altug
dc.contributor.authorCan, Gunay
dc.contributor.authorYuksel, Murat
dc.contributor.authorKoroglu, Bayram
dc.contributor.authorYuksel, Husniye
dc.date.accessioned2024-04-24T16:11:05Z
dc.date.available2024-04-24T16:11:05Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Given that serum phospholipids (PL) may serve as inflammation mediators, we studied whether they predicted metabolic syndrome (MetS), type-2 diabetes or coronary heart disease (CHD) risk in people prone to enhanced low-grade inflammation. Methods: We analyzed unselected middle-aged Turkish adults with available serum total (n = 852) and HDL-PL (n = 428) measurements and follow-up (mean 6.6 years) by Cox or logistic regression, after exclusion of prevalent cases of outcome disorder. The enzymatic method used measured total content of phosphatidylcholine, sphingomyelin and lyso-phosphatidylcholine. Results: Most lipid and non-lipid variables were significantly different in the upper two compared with the lowest total PL tertile, whereby apolipoprotein (apo)A-I and HDL-cholesterol were higher (not lower). ApoA-I. HDL-cholesterol and uric acid were uniformly positive independent linear covariates of total and HDL PI, apoA-I even in participants without MetS. After adjustment for sex, age, waist circumference. HDL-cholesterol and systolic blood pressure, logistic regression for incident MetS disclosed a 3-fold risk (RR [95% CI 1.28; 6.81]) in the upper HDL-pl tertile. In Cox regression models, while the combined two higher HDL-pl tertiles significantly protected against CHD risk in males (HR 0.29 [95% CI 0.10; 0.89]), they weakly tended to impart risk in females: upper two total PL tertiles tended to increased risk of diabetes and CHD. Conclusion: Excess total PL may mediate inflammatory properties to apoA-I. HDL and uric acid. Excess HDL-pl independently predict risk for MetS in each gender, but are protective against CHD risk in men, possibly because oxidized PL content mediated by total PL is sex-dependent, as reviewed elsewhere. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.en_US
dc.identifier.doi10.1016/j.clnu.2013.10.020
dc.identifier.endpage822en_US
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.issue5en_US
dc.identifier.pmid24246837
dc.identifier.scopus2-s2.0-84906047421
dc.identifier.scopusqualityQ1
dc.identifier.startpage815en_US
dc.identifier.urihttps://doi.org/10.1016/j.clnu.2013.10.020
dc.identifier.urihttps://hdl.handle.net/11468/15262
dc.identifier.volume33en_US
dc.identifier.wosWOS:000347745700011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofClinical Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApolipoprotein A-Ien_US
dc.subjectCoronary Heart Disease Risken_US
dc.subjectHdl-Cholesterolen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectPhospholipidsen_US
dc.subjectPopulation-Based Studyen_US
dc.titleSerum total and high-density lipoprotein phospholipids: Independent predictive value for cardiometabolic risken_US
dc.titleSerum total and high-density lipoprotein phospholipids: Independent predictive value for cardiometabolic risk
dc.typeArticleen_US

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