Retinal microvascular changes in patients with multiple myeloma: A study based on optical coherence tomography angiography

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dc.authorid0000-0003-3346-3290en_US
dc.authorid0000-0001-5742-1293en_US
dc.authorid0000-0002-3591-721Xen_US
dc.authorid0000-0001-8856-0528en_US
dc.authorid0000-0002-8206-781Xen_US
dc.authorid0000-0002-0378-8687en_US
dc.authorid0000-0003-2348-4856en_US
dc.contributor.authorDursun, Mehmet Emin
dc.contributor.authorErdem, Seyfettin
dc.contributor.authorKarahan, Mine
dc.contributor.authorAva, Sedat
dc.contributor.authorHazar, Leyla
dc.contributor.authorDursun, Birgül
dc.contributor.authorKarakaş, Abdullah
dc.contributor.authorDemircan, Vehbi
dc.contributor.authorKeklikçi, Uğur
dc.date.accessioned2023-03-21T06:47:17Z
dc.date.available2023-03-21T06:47:17Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractPurpose: Ocular microvascular networks and variables were analyzed using optical coherence tomography angiography (OCTA) in patients with multiple myeloma (MM) who had no pathological findings in their routine ophthalmologic examinations. Methods: The study included 31 patients with a diagnosis of MM and 30 healthy controls. The ophthalmologic examination findings and OCTA measurements of the participants were prospectively analyzed. We evaluated the superficial capillary plexus (SCP) vessel density (VD) and deep capillary plexus (DCP) VD in macular region, radial peripapillary capillary (RPC) VD, optic nerve head (ONH) VD and the foveal avascular zone (FAZ) area. Results: The samples were gender-balanced, and there were no significant differences in age or gender between the MM and control groups. From the OCTA, all the ONH-VD measurements, except for the peripapillary and superotemporal parameters, were found to be significantly lower in MM patients than in the control group; the same was found for the whole image, inferonasal, superonasal, and superotemporal RPC-VD values; for all the SCP-VD values, except for the inferior hemi and temporal; and for all the DCP-VD values. It was also observed that the deep FAZ area was wider in the MM group than in the control group. Conclusions: We detected decreased VD in deep and superficial macular retinal areas, papillary, peripapillary regions, suggesting decreased blood flow and possible ischemia in MM patients. Therefore, obtaining information on ischemia by using a noninvasive and easily measurable method such as OCTA, may be beneficial in terms of follow-up and treatment but this needs to be supported by further, larger studies.en_US
dc.identifier.citationDursun, M.E., Erdem, S., Karahan, M., Ava, S., Hazar, L., Dursun, B. ve diğerleri. (2022). Retinal microvascular changes in patients with multiple myeloma: A study based on optical coherence tomography angiography. Current Eye Reserach, 47(6), 874-881.en_US
dc.identifier.endpage881en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue6en_US
dc.identifier.pmid35179416
dc.identifier.scopusScopusIdYok
dc.identifier.scopusqualityQ1
dc.identifier.startpage874en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/02713683.2022.2034886
dc.identifier.urihttps://hdl.handle.net/11468/11462
dc.identifier.volume47en_US
dc.identifier.wosWOS:000771824400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDursun, Mehmet Emin
dc.institutionauthorErdem, Seyfettin
dc.institutionauthorKarahan, Mine
dc.institutionauthorAva, Sedat
dc.institutionauthorHazar, Leyla
dc.institutionauthorKarakaş, Abdullah
dc.institutionauthorDemircan, Vehbi
dc.institutionauthorKeklikçi, Uğur
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofCurrent Eye Reserach
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFoveal avascular zoneen_US
dc.subjectMultiple myelomaen_US
dc.subjectOptical coherence tomography angiographyen_US
dc.subjectVascular densityen_US
dc.titleRetinal microvascular changes in patients with multiple myeloma: A study based on optical coherence tomography angiographyen_US
dc.titleRetinal microvascular changes in patients with multiple myeloma: A study based on optical coherence tomography angiography
dc.typeArticleen_US

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