Effect of granulocyte-macrophage colony-stimulating factor on treatment of acute osteomyelitis - An experimental investigation in rats

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dc.contributor.authorSubasi, M
dc.contributor.authorKapukaya, A
dc.contributor.authorKesemenli, C
dc.contributor.authorKaya, H
dc.contributor.authorSari, I
dc.date.accessioned2024-04-24T16:00:15Z
dc.date.available2024-04-24T16:00:15Z
dc.date.issued2001
dc.departmentDicle Üniversitesien_US
dc.description.abstractGranulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that affects the various developmental steps of hematopoietic cells and enhances the phagocytic activity of these cells. The effect of GM-CSF on acute osteomyelitis, developed in rats, was investigated. For this purpose, osteomyelitis was firstly developed through the direct inoculation of Staphylococcus aureus into rat tibial metaphysis. Twenty-four rats in which diagnosis of osteomyelitis was histopathologically established were divided into two groups. Antibiotic only was given to the first group, and antibiotic as well as CM-CSF to the second roup. Rats were followed up for 3 months with plain radiographs and scintigraphic methods using (67)Gacitrate. Material obtained from the rats that had been killed at the end of the 3rd month were histopathologicalIy investigated. One rat in the first group died. In another rat, chronic osteomyelitis developed and fracture was observed. In 12 rats of the second group, physical examination, plain radiographs, and histopathologic findings were normal. In scintigraphic studies with Ga-67-citrate, when the pre- and posttreatment values of the same groups were evaluated by the Mann-Whitney U-test, the mean values at 48 h after treatment were found to be significant (P < 0.05), indicating a decrease in the 2nd group (experimental group). In conclusion, the antibiotics were effective in the elimination of infection only together with neutrophils. In this manner, infections may be eliminated by strengthening the host's defense mechanism as well as by administering antibiotics. We believe that an adequate number of long-term studies will shed light on this issue. Besides we consider that this factor will be more important in the study of chronic osteomyelitis.en_US
dc.identifier.doi10.1007/s004020000209
dc.identifier.endpage173en_US
dc.identifier.issn0936-8051
dc.identifier.issue3en_US
dc.identifier.pmid11262785
dc.identifier.scopus2-s2.0-0035108638
dc.identifier.scopusqualityQ1
dc.identifier.startpage170en_US
dc.identifier.urihttps://doi.org/10.1007/s004020000209
dc.identifier.urihttps://hdl.handle.net/11468/14415
dc.identifier.volume121en_US
dc.identifier.wosWOS:000167269700012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofArchives of Orthopaedic and Trauma Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGranulocyte-Macrophage Colony-Stimulatingen_US
dc.subjectFactoren_US
dc.subjectOsteomyelitisen_US
dc.titleEffect of granulocyte-macrophage colony-stimulating factor on treatment of acute osteomyelitis - An experimental investigation in ratsen_US
dc.titleEffect of granulocyte-macrophage colony-stimulating factor on treatment of acute osteomyelitis - An experimental investigation in rats
dc.typeArticleen_US

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