Placental expression of vimentin, desmin and ultrastructural changes in the villi in patients with HELLP syndrome

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dc.contributor.authorSak, M. E.
dc.contributor.authorDeveci, E.
dc.contributor.authorTurgut, A.
dc.contributor.authorSak, S.
dc.contributor.authorEvsen, M. S.
dc.contributor.authorGul, T.
dc.contributor.authorKalkanli, S.
dc.date.accessioned2024-04-24T17:37:46Z
dc.date.available2024-04-24T17:37:46Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVES: To examine placental expression of vimentin and desmin in relation to ultrastructural changes within the placental villi in cases of HELLP syndrome. STUDY DESIGN: Formaldehyde-fixed and paraffin- embedded specimens of 15 healthy pregnant and 13 Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, placentas were used for Harris hematoxylin staining, vimentin and desmin immunohistochemistry, and transmission electron microscopy (TEM). RESULTS: Increased of fibrinoid necrosis in vascular wall and the periphery of villi were observed in sections of the placentas with HELLP syndrome. Increased expression of vimentin in the intravillous area and increased expression of desmin on blood vessel wall, were seen in placentas of patients with HELLP syndrome when compared to placentas of healthy pregnant. CONCLUSIONS: Augmentation of intermediate filaments, desmin, vimentin may disturb normal movements of endothelial cells, and may display placental dysfunction that is unable to compensate the endothelial instability and the related hypertension in HELLP syndrome. Further studies are needed to get more definit results and also to compare HELLP syndrome with preeclampsia.en_US
dc.identifier.endpage878en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid23640432
dc.identifier.scopus2-s2.0-84878584000
dc.identifier.scopusqualityQ2
dc.identifier.startpage874en_US
dc.identifier.urihttps://hdl.handle.net/11468/21169
dc.identifier.volume17en_US
dc.identifier.wosWOS:000325207600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHellp Syndromeen_US
dc.subjectPlacental Expressionen_US
dc.subjectVimentinen_US
dc.subjectDesminen_US
dc.titlePlacental expression of vimentin, desmin and ultrastructural changes in the villi in patients with HELLP syndromeen_US
dc.titlePlacental expression of vimentin, desmin and ultrastructural changes in the villi in patients with HELLP syndrome
dc.typeArticleen_US

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