Evaluation of serum transforming growth factor ?1 and C-reactive protein levels in migraine patients

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dc.contributor.authorGuzel, Isil
dc.contributor.authorTasdemir, Nebahat
dc.contributor.authorCelik, Yusuf
dc.date.accessioned2024-04-24T17:24:52Z
dc.date.available2024-04-24T17:24:52Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and purpose: Migraine is a frequent form of headache. Although many mechanisms describing onset of migraine with and without visual aura have been suggested, the aetiology of migraine headaches is still not clear. Neurogenic inflammation may play a key role in the development of migraine headaches. We evaluated the discriminative power of serum levels of C-reactive protein (CRP) and transforming growth factor beta 1 (TGF-beta 1) in patients who presented to our clinic with migraine headaches with or without visual aura. Material and methods: We designed a prospective case-control study of 51 patients with migraine (27 with migraine with aura and 24 with migraine without aura; all had headache) and compared them with 27 healthy subjects during the study period. Demographic and clinical characteristics recorded were age, sex, marital status, occupation, characteristics of headache, laboratory values, and serum CRP and TGF-beta 1 levels. Statistical analyses used Student t-test, the chi(2) test, and AN OVA followed by the post-hoc Bonferroni test for multiple comparisons. Receiver operator characteristic (ROC)-curve analysis for CRP and TGF-beta 1 was also conducted. Result: There was no difference between the groups in terms of demographic characteristics, marital status, and socioeconomic status. Statistically, white blood cell levels, serum glucose levels, triglyceride levels, high-density lipoprotein levels, and serum CRP and TGF-beta 1 were significantly higher in patients with migraine (p < 0.05). The ROC curve results in this study identified that CRP and TGF-beta 1 may discriminate patients who have different types of migraine headache. Conclusions: This study suggests that serum CRP and TGF-beta 1 levels may be diagnostic factors to differentiate migraine patients with and without aura. These findings show that neurogenic inflammation may have a role in the aetiology of migraines.en_US
dc.identifier.doi10.5114/ninp.2013.36760
dc.identifier.endpage362en_US
dc.identifier.issn0028-3843
dc.identifier.issn1897-4260
dc.identifier.issue4en_US
dc.identifier.pmid23986426
dc.identifier.scopus2-s2.0-84881503618
dc.identifier.scopusqualityQ1
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.5114/ninp.2013.36760
dc.identifier.urihttps://hdl.handle.net/11468/19862
dc.identifier.volume47en_US
dc.identifier.wosWOS:000324153900008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofNeurologia I Neurochirurgia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraineen_US
dc.subjectAetiologyen_US
dc.subjectNeurogenic Inflammationen_US
dc.subjectCrpen_US
dc.subjectTgf-Beta 1en_US
dc.titleEvaluation of serum transforming growth factor ?1 and C-reactive protein levels in migraine patientsen_US
dc.titleEvaluation of serum transforming growth factor ?1 and C-reactive protein levels in migraine patients
dc.typeArticleen_US

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