Investigation of the relationship of growth hormone, insulin-like growth factor (IGF)-1, and IGF-binding protein-3 levels with graft viability in autograft-transplanted pediatric patients with major burns

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dc.contributor.authorAkkoc, Mehmet Fatih
dc.contributor.authorKapi, Emin
dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorKarakol, Percin
dc.date.accessioned2024-04-24T16:18:32Z
dc.date.available2024-04-24T16:18:32Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: In our study, we investigated graft viability, Growth Hormone (GH), Insulin-like growth factor (IGF)1, and IGF-binding protein (IGFBP)-3 in autograft-transplanted pediatric major burn cases.Methods: This descriptive study was conducted with the participation of pediatric patients with major burn wounds. The laboratory data and characteristics of the patients were accessed retrospectively, and the obtained data were recorded in the data form developed by the researchers. In the analysis of the data, descriptive statistical methods, chi-squared test, Wilcoxon signed-rank test, one-way ANOVA, and post hoc analyses were used.Results: The sample of our study consisted of 93 pediatric major burn patients with a total burnt body surface area of more than 20%. It was found that 65.59% of the patients were between the ages of 1 and 5, 63.43% of them were in the 41-55 percentile range, 58.06% had a hot liquid burn, 74.2% had a second-degree burn, 60.21% had a burn percentage in the range of 21-40 of their total body surface area. It was determined that the GH and IGF-1 levels of the patients who experienced loss after graft transplantation remained below the normal value in the first 14 days, and the differences in the GH and IGF-1 values between the patients with good functioning grafts and those with graft loss were statistically significant (p < 0.01). It was found that the IGFBP-3 value remained low on the 14th day in the patients with good functioning grafts, and the difference in the IGFBP-3 values between the patients with good functioning grafts and those with graft loss was statistically significant (p < 0.05).Conclusion: Today, it is known that the parameters of GH, IGF-1, and IGFBP-3 are related to many problems. However, no study examining their relationships with graft viability in autograft-transplanted pediatric patients with major burns was encountered. Our study may be the first to determine that changes in these three laboratory parameters negatively affect the healing of burn wounds.en_US
dc.identifier.doi10.1016/j.trim.2022.101624
dc.identifier.issn0966-3274
dc.identifier.issn1878-5492
dc.identifier.pmid35577268
dc.identifier.scopus2-s2.0-85130371737
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.trim.2022.101624
dc.identifier.urihttps://hdl.handle.net/11468/16151
dc.identifier.volume73en_US
dc.identifier.wosWOS:000806364800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTransplant Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutograft Transplantationen_US
dc.subjectAutograft Viabilityen_US
dc.subjectGrowth Hormoneen_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectInsulin-Like Growth Factor-Binding Proteinsen_US
dc.subject(Igfbp)-3en_US
dc.subjectPediatric Major Pediatric Burn Patientsen_US
dc.titleInvestigation of the relationship of growth hormone, insulin-like growth factor (IGF)-1, and IGF-binding protein-3 levels with graft viability in autograft-transplanted pediatric patients with major burnsen_US
dc.titleInvestigation of the relationship of growth hormone, insulin-like growth factor (IGF)-1, and IGF-binding protein-3 levels with graft viability in autograft-transplanted pediatric patients with major burns
dc.typeArticleen_US

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