Early Stepdown Weaning of Dairy Calves with Glutamine and Branched-Chain Amino Acid Supplementations

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dc.contributor.authorWickramasinghe, Janaka
dc.contributor.authorKaya, Can Ayhan
dc.contributor.authorBeitz, Donald
dc.contributor.authorAppuhamy, Ranga
dc.date.accessioned2024-04-24T17:20:50Z
dc.date.available2024-04-24T17:20:50Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractSimple Summary We demonstrated previously that supplementation of glutamine (Gln) at 2.0% of dry matter intake (DMI) increased the rate at which dairy calves achieved >= 1.0 kg/d starter feed intake (SFI) during weaning. Because Gln supplements at <1.0% of DMI or branched-chain amino acid (BCAA) supplements have been shown to improve the performance of weaning piglets, we examined the effects of a lower dose of Gln (8.0 g/d equivalent to 1% of DMI) alone or in combination with BCAA supplementations on SFI and average daily gain (ADG) in this study. Amino acids did not affect SFI or ADG during the supplementations but decreased post-weaning SFI in an additive manner even though the ADG was not affected. The blood analysis on the last day of supplementations revealed a possibility for the Gln and BCAA supplementations to suppress SFI through leptin and serotonin secreted by the gastrointestinal tract. The study objective was to examine the effects of supplementing Gln and BCAA on the SFI and ADG of weaning dairy calves. Holstein heifer calves (11 calves /treatment) at 35 d of age were assigned to: (1) no amino acids (CTL), (2) Gln (8.0 g/d) alone (GLN), or (3) Gln (8.0 g/d) and BCAA (GLNB; 17.0, 10.0, and 11.0 g/d leucine, isoleucine, and valine, respectively) supplementations in whole milk during a stepdown weaning scheme. Calves were weaned completely once they achieved >= 1.0 kg/d SFI. Neither GLN nor GLNB affected SFI or ADG in the first week during weaning. The GLNB decreased SFI compared to CTL, but the SFI was similar between CTL and GLN in the remainder of the weaning scheme. All calves were weaned at 50 d of age. The SFI of GLNB was lower than that of GLN, and the SFI of both GLN and GLNB were lower than CTL post-weaning. The decreased SFI did not alter ADG during weaning or post-weaning. The GLNB tended to have higher plasma leptin and lower plasma serotonin concentrations compared to CTL. Glutamine and BCAA seem to affect the SFI of calves by modulating the secretions of endocrine cells in the gastrointestinal tract.en_US
dc.description.sponsorshipW.M. Keck Metabolomics Research Laboratory at Iowa State University (Ames, IA, USA)en_US
dc.description.sponsorshipWe are thankful to the staff at the Dairy Research and Teaching Farm of Iowa State University (Ames, IA, USA). We also appreciate the technical advice and support of W.M. Keck Metabolomics Research Laboratory at Iowa State University (Ames, IA, USA).en_US
dc.identifier.doi10.3390/ani12121474
dc.identifier.issn2076-2615
dc.identifier.issue12en_US
dc.identifier.pmid35739810
dc.identifier.scopus2-s2.0-85131304788
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ani12121474
dc.identifier.urihttps://hdl.handle.net/11468/19265
dc.identifier.volume12en_US
dc.identifier.wosWOS:000817591400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofAnimals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBranched-Chain Amino Acidsen_US
dc.subjectDairy Calvesen_US
dc.subjectGlutamineen_US
dc.subjectStarter Feed Intakeen_US
dc.titleEarly Stepdown Weaning of Dairy Calves with Glutamine and Branched-Chain Amino Acid Supplementationsen_US
dc.titleEarly Stepdown Weaning of Dairy Calves with Glutamine and Branched-Chain Amino Acid Supplementations
dc.typeArticleen_US

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