Curcumin exerts protective effects against valproic acid-induced testicular damage through modulating the JAK1/STAT-3/IL-6 signaling pathway in rats

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dc.contributor.authorDokumacioglu, Eda
dc.contributor.authorIskender, Hatice
dc.contributor.authorKapakin, Kubra Asena Terim
dc.contributor.authorBolat, Ismail
dc.contributor.authorMokhtare, Behzat
dc.contributor.authorOmur, Ali Dogan
dc.contributor.authorHayirli, Armagan
dc.date.accessioned2025-02-22T14:08:44Z
dc.date.available2025-02-22T14:08:44Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective(s): This experiment was carried out to investigate the protective effects of curcumin (CUR) on testicular damage induced by the valproic acid (VPA) administration. Materials and Methods: Male Wistar-Albino rats (n=28, 250-300 g) were randomly divided into four groups: Control (1 ml saline, oral), VPA (500 mg/kg, IP), CUR (200 mg/kg, oral), or VPA+CUR (500 mg/kg, VPA, IP plus 200 mg/kg CUR, oral). The treatments were applied for 14 days. Serum testosterone and testis [Janus kinases1 (JAK1), signal transducers and activators of transcription-3 interleukin-18 (IL-18), and nuclear factor (NF)-kappa B)] samples were collected for biochemical analyses. Semen samples were subjected to microscopy for spermatological parameters. Testis tissue was also analyzed for histopathological and immunohistochemical methods. Results: The VPA administration caused a 37% decrease in serum testosterone concentration and 5.32, 9.51, 2.44, and 3.68-fold increases in testicular tissue JAK1, STAT-3, IL-6, and MDA levels, respectively. There were also 50, 52, and 72% reductions in sperm motility, sperm viability, and the mean testicular biopsy score, respectively, accompanied by considerable degenerative changes and necrosis in seminiferous tubules in the VPA group. There is also an immune-positive reaction for IL-18 and NF-kappa B in only Leydig cells. Conclusion: The CUR treatment may be beneficial in restoring testicular damage through antiinflammatory and anti-oxidant potential.en_US
dc.description.sponsorshipCoordinator of Scientific Research Projects at Artvin Coruh University, Turkey [2020.M84.02.01]en_US
dc.description.sponsorshipThis work was supported by the Coordinator of Scientific Research Projects [2020.M84.02.01] at Artvin Coruh University, Turkey.en_US
dc.identifier.doi10.22038/ijbms.2024.76948.16659
dc.identifier.endpage236en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue2en_US
dc.identifier.pmid39850114en_US
dc.identifier.scopus2-s2.0-85214461495en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.22038/ijbms.2024.76948.16659
dc.identifier.urihttps://hdl.handle.net/11468/29608
dc.identifier.volume28en_US
dc.identifier.wosWOS:001379175400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectCurcuminen_US
dc.subjectInterleukin-6en_US
dc.subjectJanus kinasesen_US
dc.subjectTesticular damageen_US
dc.subjectValproic aciden_US
dc.titleCurcumin exerts protective effects against valproic acid-induced testicular damage through modulating the JAK1/STAT-3/IL-6 signaling pathway in ratsen_US
dc.typeArticleen_US

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