Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

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dc.contributor.authorGündüz, Reyhan
dc.contributor.authorUğur, Mete Gürol
dc.contributor.authorÖzcan, Hüseyin
dc.contributor.authorTaysı, Seyithan
dc.contributor.authorTepe, Neslihan
dc.contributor.authorDemir, Sevgi Sarı
dc.contributor.authorBalat, Özcan
dc.date.accessioned2024-04-24T19:11:50Z
dc.date.available2024-04-24T19:11:50Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levelsin patients with first trimester miscarriage.Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdGlevels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDAlevels were also measured in both groups.Results: There wasn’t difference in terms of complete blood count, thyroid-stimulating hormone (TSH), homocysteinevalues, parity, age, body mass index (BMI) and gestational age between the groups. Serum 8-OHdG and MDA levels weresignificantly higher in the patient group (p=0.001). A moderate positive significant correlation between the gestationalweek and MDA values and a weak but significant positive correlation between 8-OHdG values and gestational week weredetected in the patient group.Conclusion: 8-OHdG and MDA could play a role in the etiopathogenesis of first-trimester miscarriage. However, this rolemust be further delineated in large-scaled studies for early diagnosis and management of this condition.en_US
dc.identifier.doi10.5798/dicletip.706022
dc.identifier.endpage81en_US
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue1en_US
dc.identifier.startpage74en_US
dc.identifier.trdizinid370609
dc.identifier.urihttps://doi.org/10.5798/dicletip.706022
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/370609
dc.identifier.urihttps://hdl.handle.net/11468/28217
dc.identifier.volume47en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofDicle Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Studyen_US
dc.titleEvaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study
dc.typeArticleen_US

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