Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

Objective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levelsin patients with first trimester miscarriage.Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdGlevels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDAlevels were also measured in both groups.Results: There wasn’t difference in terms of complete blood count, thyroid-stimulating hormone (TSH), homocysteinevalues, parity, age, body mass index (BMI) and gestational age between the groups. Serum 8-OHdG and MDA levels weresignificantly higher in the patient group (p=0.001). A moderate positive significant correlation between the gestationalweek and MDA values and a weak but significant positive correlation between 8-OHdG values and gestational week weredetected in the patient group.Conclusion: 8-OHdG and MDA could play a role in the etiopathogenesis of first-trimester miscarriage. However, this rolemust be further delineated in large-scaled studies for early diagnosis and management of this condition.