The protective role of pomegranate juice against carbon tetrachloride-induced oxidative stress in rats

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dc.contributor.authorPirinccioglu, Mihdiye
dc.contributor.authorKizil, Goksel
dc.contributor.authorKizil, Murat
dc.contributor.authorKanay, Zeki
dc.contributor.authorKetani, Aydin
dc.date.accessioned2024-04-24T17:14:35Z
dc.date.available2024-04-24T17:14:35Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractMost pomegranate (Punica granatum Linn., Punicaceae) fruit parts are known to possess enormous antioxidant activity. The present study was carried out to determine the phenolic and flavonoid contents of Derik pomegranate juice and determine its effect against carbon tetrachloride (CCl4)-induced toxicity in rats. Animals were divided into four groups (n=6): group I: control, group II: CCl4 (1ml/kg), group III: CCl4+pomegranate juice and group IV: CCl4+ursodeoxycholic acid (UDCA). Treatment duration was 4weeks, and the dose of CCl4 was administered once a week to groups II, III and IV during the experimental period. CCl4-treated rats caused a significant increase in serum enzyme levels, such as aspartate aminotransferase, alanine aminotransferase and total bilirubin, and decrease in albumin, when compared with control. Administration of CCl4 along with pomegranate juice or UDCA significantly reduces these changes. Analysis of lipid peroxide (LPO) levels by thiobarbutiric acid reaction showed a significant increase in liver, kidney and brain tissues of CCl4-treated rats. However, both pomegranate juice and UDCA prevented the increase in LPO level. Histopathological reports also revealed that there is a regenerative activity in the liver and kidney cells. Derik pomegranate juice showed to be hepatoprotective against CCl4-induced hepatic injury. In conclusion, present study reveals a biological evidence that supports the use of pomegranate juice in the treatment of chemical-induced hepatotoxicity.en_US
dc.description.sponsorshipDicle University Research Foundation, Turkey [09-FF-44]en_US
dc.description.sponsorshipThis work was supported by grants from Dicle University Research Foundation (Project no.: 09-FF-44), Turkey.en_US
dc.identifier.doi10.1177/0748233712464809
dc.identifier.endpage918en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue10en_US
dc.identifier.pmid23160382
dc.identifier.scopus2-s2.0-84911377153
dc.identifier.scopusqualityQ2
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712464809
dc.identifier.urihttps://hdl.handle.net/11468/18080
dc.identifier.volume30en_US
dc.identifier.wosWOS:000343774400006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPomegranate Juiceen_US
dc.subjectUrsodeoxycholic Aciden_US
dc.subjectCarbon Tetrachloride Toxicityen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Activityen_US
dc.titleThe protective role of pomegranate juice against carbon tetrachloride-induced oxidative stress in ratsen_US
dc.titleThe protective role of pomegranate juice against carbon tetrachloride-induced oxidative stress in rats
dc.typeArticleen_US

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