A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective study

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dc.authorid0000-0002-3285-9990en_US
dc.contributor.authorEge, Serhat
dc.contributor.authorBademkıran, Muhammed Hanifi
dc.contributor.authorPeker, Nurullah
dc.contributor.authorTahaoǧlu, Ali Emre
dc.contributor.authorÇaça, Fatma Nur Hançer
dc.contributor.authorÖzçelik, Serap Mutlu
dc.date.accessioned2021-08-25T06:03:08Z
dc.date.available2021-08-25T06:03:08Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractObjectives: The aim of this study was to compare a combination treatment with CC plus letrozole versus gonadotropins in CC-resistant polycystic ovary syndrome (PCOS) patients with regard to ovulation and clinical pregnancy rate. Material and methods: One hundred sixteen CC-resistant infertile PCOS patients were evaluated retrospectively. The patients were divided into two groups. Group 1 (n = 73) received CC plus letrozole, and Group 2 (n = 43) received gonadotropins. Results: The ovulation rate in Group 1 was 65/73 (89%), the pregnancy rate was 13/73 (18%), the twin foetuses rate was 1/73 (1.3%) and the miscarriage rate was 2/73 (2.7%). In Group 2, the ovulation rate was 41/43 (95%), and the pregnancy rate was 8/43 (19%) the rate of the twin foetuses was 1/43 (2.3%) and the miscarriage rate was 1/43 (2.3%). There was no statistically significant difference in the ovulation (p = 0.25), pregnancy (p = 0.91), twin foetuses (p = 0.89) and miscarriage p = 0.89) rates between two groups. Conclusions: This new drug combination suggests that it may be a lower cost, lower risk alternative treatment that increases the rate of ovulation. Larger randomized clinical trials are needed to provide information on live birth rates of this combination.en_US
dc.identifier.citationEge, S., Bademkıran, M. H., Peker, N., Tahaoǧlu, A. E., Çaça, F. N. H. ve Özçelik, S. M. (2020). A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective study. Ginekologia Polska, 91(4), 185-188.en_US
dc.identifier.doi10.5603/GP.A2020.0037
dc.identifier.endpage188en_US
dc.identifier.issn0017-0011
dc.identifier.issue4en_US
dc.identifier.pmid32236935
dc.identifier.scopus2-s2.0-85085578260
dc.identifier.scopusqualityQ3
dc.identifier.startpage185en_US
dc.identifier.urihttps://journals.viamedica.pl/ginekologia_polska/article/view/66652
dc.identifier.urihttps://hdl.handle.net/11468/7385
dc.identifier.volume91en_US
dc.identifier.wosWOS:000531857500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPeker, Nurullah
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClomiphene resistanceen_US
dc.subjectGonadotropinsen_US
dc.subjectLetrozoleen_US
dc.subjectOvulation inductionen_US
dc.subjectPolycystic ovary syndromeen_US
dc.titleA comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective studyen_US
dc.titleA comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective study
dc.typeArticleen_US

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