Chemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum

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dc.contributor.authorBoga, Mehmet
dc.contributor.authorYilmaz, Pelin Koseoglu
dc.contributor.authorCebe, Deniz Baris
dc.contributor.authorFatima, Mashhad
dc.contributor.authorSiddiqui, Bina S.
dc.contributor.authorKolak, Ufuk
dc.date.accessioned2024-04-24T17:27:52Z
dc.date.available2024-04-24T17:27:52Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractTwo endemic Cirsium species, C. leucopsis DC. and C. sipyleum O. Schwarz, and C. eriophorum (L.) Scop. growing in Turkey were investigated to establish their secondary metabolites, fatty acid compositions, and antioxidant and anticholinesterase potentials. Spectroscopic methods were used to elucidate the structures of thirteen known compounds (p-hydroxy-benzoic acid, vanillic acid, cis-epoxyconiferyl alcohol, syringin, balanophonin, 1'-O-methyl-balanophonin, apigenin, kaempferol-3-O-beta-D-glucopyranoside, kaempferol-3-O-alpha-L-rhamnopyranoside, taraxasterol, taraxasterol acetate, beta-sitosterol, beta-sitosterol-3-O-beta-D-glucopyranoside). cis-Epoxyconiferyl alcohol and 1'-O-methyl-balanophonin were isolated for the first time from Cirsium species. Palmitic acid (47.1%) was found to be the main fatty acid of C. leucopsis, linoleic acid in both C. sipyleum (42.1%) and C. eriophorum (37.8%). Assays of beta-carotene bleaching, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium (ABTS) cation radicals, and superoxide anion radicals, as well as cupric reducing antioxidant capacity (CUPRAC) were used to determine the antioxidant activities of the extracts and isolated compounds. Vanillic acid, balanophonin, and kaempferol-3-O-alpha-L-rhamnopyranoside exhibited strong antioxidant activity. Taraxasterol was a potent inhibitor of acetyl- and butyrylcholinesterase activity, respectively.en_US
dc.description.sponsorshipIstanbul University [4802]; Batman University [BATUBAP-2011-FED-2]en_US
dc.description.sponsorshipThis study is a part of Mehmet Boga's Ph.D. thesis. The authors are grateful to the Research Fund of Istanbul University (Project number: 4802) and to the Research Fund of Batman University (BATUBAP-2011-FED-2) for support. We are also grateful to the H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, for providing laboratory facilities.en_US
dc.identifier.doi10.5560/ZNC.2014-0071
dc.identifier.endpage390en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue9-10en_US
dc.identifier.pmid25711039
dc.identifier.scopus2-s2.0-84925354214
dc.identifier.scopusqualityQ2
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.5560/ZNC.2014-0071
dc.identifier.urihttps://hdl.handle.net/11468/20229
dc.identifier.volume69en_US
dc.identifier.wosWOS:000348967800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal of Biosciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCirsiumen_US
dc.subjectSecondary Metabolitesen_US
dc.subjectBiological Activityen_US
dc.titleChemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorumen_US
dc.titleChemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum
dc.typeArticleen_US

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