Functional characteristics of the growth factor receptor family and some ligands in the oropharyngeal cavity of the Chukar partridge (Alectoris chukar)

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dc.contributor.authorSaruhan, Berna G.
dc.contributor.authorSagsoz, Hakan
dc.contributor.authorAkbalik, Mehmet E.
dc.contributor.authorErdogan, Serkan
dc.date.accessioned2024-04-24T16:24:17Z
dc.date.available2024-04-24T16:24:17Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstract1. The aim of the present study is to describe, immunohistochemically, the expression and cell type localisation of growth factor receptors and some of their ligands in the oropharyngeal organs of the Chukar partridge. 2. The tissue samples from 10 healthy adult partridges were dissected under ether anaesthesia and then embedded in paraffin following routine histological procedures. The immunoreaction for receptors and ligands of the epidermal growth factor receptor (EGFR)/ligand system was localised in the cell membrane, nucleus and cytoplasm of the luminal and glandular epithelial cells, stromal and striated muscle cells, and vascular endothelial and smooth muscle cells. 3. Variations were observed in the avian oropharyngeal organs. The immunostaining for the erbB1/HER1 (human epidermal growth factor receptor 1) and the EGF (epidermal growth factor) and AREG (Amphiregulin) ligands in the luminal epithelial cells was higher than in the glandular epithelial, stromal and striated muscle cells. However, the immunostaining for erbB3/HER3 (human epidermal growth factor receptor 3) and erbB4/HER4 (human epidermal growth factor receptor 4) were similar in the luminal epithelium, stromal and striated muscle cells. 4. Growth factor receptors and some of their ligands were localised in different cell types in the oropharyngeal organs. We suggest that erbB/HERs (human epidermal growth factor receptors) and their ligands play an important role in proliferation, differentiation, growth, survival and migration of the cells.en_US
dc.identifier.doi10.1080/00071668.2015.1099611
dc.identifier.endpage686en_US
dc.identifier.issn0007-1668
dc.identifier.issn1466-1799
dc.identifier.issue6en_US
dc.identifier.pmid26569385
dc.identifier.scopus2-s2.0-84954404208
dc.identifier.scopusqualityQ1
dc.identifier.startpage673en_US
dc.identifier.urihttps://doi.org/10.1080/00071668.2015.1099611
dc.identifier.urihttps://hdl.handle.net/11468/16630
dc.identifier.volume56en_US
dc.identifier.wosWOS:000371284900009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleFunctional characteristics of the growth factor receptor family and some ligands in the oropharyngeal cavity of the Chukar partridge (Alectoris chukar)en_US
dc.titleFunctional characteristics of the growth factor receptor family and some ligands in the oropharyngeal cavity of the Chukar partridge (Alectoris chukar)
dc.typeArticleen_US

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