Serum prolidase activity and oxidative status in patients with diabetic neuropathy

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dc.contributor.authorUzar, Ertugrul
dc.contributor.authorTamam, Yusuf
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBeyaz, Coskun
dc.contributor.authorAcar, Abdullah
dc.contributor.authorAydin, Birsen
dc.date.accessioned2024-04-24T16:02:00Z
dc.date.available2024-04-24T16:02:00Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe found no data in the literature related to oxidative stress index (OSI), total oxidative status (TOS) and prolidase activity in patients with diabetic neuropathy (DN). In this study, we aimed to evaluate the oxidative status of DN patients via measurement of TOS and serum total antioxidant status (TAS) and estimation of OSI using new automated methods. Thirty-eight healthy participants, 40 diabetic patients without neuropathy, and 39 patients with DN were included. Electrophysiological and neurological examinations were performed. The activity of prolidase and levels of TOS and TAS were determined in the serum of patients. The level of TAS was lower, while the levels of TOS and OSI, and activity of prolidase were higher in both DN and diabetic control groups compared with the healthy subjects (p < 0.05). Prolidase activity was found to be higher in the DN group than in the diabetic control group (p = 0.001). In conclusion, the presence of high TOS and OSI levels together with low levels of TAS in diabetic patients with or without neuropathy may support a role of oxidative stress in the pathogenesis of diabetes mellitus. In addition, increased serum prolidase activity in DN may be interpreted as evidence of increased collagen turnover.en_US
dc.identifier.doi10.1007/s10072-011-0857-0
dc.identifier.endpage880en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue4en_US
dc.identifier.pmid22120188
dc.identifier.scopus2-s2.0-84863990462
dc.identifier.scopusqualityQ1
dc.identifier.startpage875en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-011-0857-0
dc.identifier.urihttps://hdl.handle.net/11468/14566
dc.identifier.volume33en_US
dc.identifier.wosWOS:000306551000021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic Neuropathyen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectProlidaseen_US
dc.titleSerum prolidase activity and oxidative status in patients with diabetic neuropathyen_US
dc.titleSerum prolidase activity and oxidative status in patients with diabetic neuropathy
dc.typeArticleen_US

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