Increased fibrinogen, D-dimer and galectin-3 levels in patients with migraine

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dc.contributor.authorYucel, Yavuz
dc.contributor.authorTanriverdi, Halis
dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorVarol, Sefer
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorAkil, Esref
dc.contributor.authorCelepkolu, Tahsin
dc.date.accessioned2024-04-24T16:02:01Z
dc.date.available2024-04-24T16:02:01Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractThere are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism, d-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and d-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and d-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and d-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and d-dimer compared to the healthy controls (p < 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (p > 0.05). Migraine patients had higher d-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (p = 0.05). In conclusion, we found increased levels of fibrinogen, d-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher d-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.en_US
dc.identifier.doi10.1007/s10072-013-1542-2
dc.identifier.endpage549en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue4en_US
dc.identifier.pmid24057117
dc.identifier.scopus2-s2.0-84897062195
dc.identifier.scopusqualityQ1
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-013-1542-2
dc.identifier.urihttps://hdl.handle.net/11468/14570
dc.identifier.volume35en_US
dc.identifier.wosWOS:000333123500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectPathogenesisen_US
dc.subjectFibrinogenen_US
dc.subjectGalectin-3en_US
dc.subjectD-Dimeren_US
dc.titleIncreased fibrinogen, D-dimer and galectin-3 levels in patients with migraineen_US
dc.titleIncreased fibrinogen, D-dimer and galectin-3 levels in patients with migraine
dc.typeArticleen_US

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