Insight into isolation and elucidation of cytotoxic ergostanoids from the mushroom Sarcosphaera crassa (Santi) Pouzar: An edible mushroom

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dc.authorid0000-0002-2193-8386en_US
dc.contributor.authorUllah, Zain
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorWahab, Atia-tul
dc.contributor.authorBen Mansour, Riadh
dc.contributor.authorChoudhry, M. Iqbal
dc.date.accessioned2023-04-06T12:01:01Z
dc.date.available2023-04-06T12:01:01Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.description.abstractSarcosphaera crassa is a mushroom consumed in Europe and Anatolia after being cooked well. The cytotoxic activity of the extracts of unbaked S. crassa against MCF7, HT29, HeLa cancer cell lines and toxicity against PDF fibroblast healthy cell lines were studied using MTT assay. Acetone and methanol extracts of the mushroom exhibited significant cytotoxic activity. Further investigation of cytotoxic extracts afforded two new fatty acid sterols (1-2), a new ergosterol glycoside (4), and seven known compounds, including a fatty acid sterol (3), a steroid glycoside (5), two ergostanoids (6-7) and three sugars (8-10). These compounds were identified as brassicasteryl heptadecanoate (1), brassicasteryl palmitoleate (2), brassicasteryl linoleate (3), brassicasterol beta-?-xylofuranoside (4), brassicasterol beta-?-glucoside (5), brassicasterol (6), ergosterol-endoperoxide (7), mannitol (8), erythritol (9) and turanose (10). Among them, 7 exhibited a moderate cytotoxic activity against HeLa (IC50: 70.1 +/-& nbsp; 2.0 mu g/mL) and high activity against HT29 (IC50: 38.8 +/- 0.9 mu g/mL), and MCF7 (IC50: 62.9 +/- 1.3 mu g/mL) cancer cell lines. Compounds 4, 5, and 6 also exhibited significant cytotoxic activity against HT29 and MCF7. Moreover, all compounds exhibited weak toxicity against PDF healthy cell lines. This study indicates the potential use of Sarcosphaera crassa as a natural source of cytotoxic ergostanoids, which can be considered a dietary supplement for cancer prevention.& nbsp;en_US
dc.identifier.citationUllah, Z., Öztürk, M., Ertaş, A., Wahab, A.T., Ben Mansour, R. ve Choudhry, M.I. (2022). Insight into isolation and elucidation of cytotoxic ergostanoids from the mushroom Sarcosphaera crassa (Santi) Pouzar: An edible mushroom. Steroids, 181,108990.en_US
dc.identifier.doi10.1016/j.steroids.2022.108990
dc.identifier.endpage8en_US
dc.identifier.issn0039-128X
dc.identifier.issn1878-5867
dc.identifier.pmid35218860
dc.identifier.scopus2-s2.0-85125280160
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0039128X22000289?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/11625
dc.identifier.volume181en_US
dc.identifier.wosWOS:000789657400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErtaş, Abdulselam
dc.language.isoenen_US
dc.publisherElsevier Science INC.en_US
dc.relation.ispartofSteroids
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSarcosphaera crassa (Santi) Pouzaren_US
dc.subjectPoisonous mushroomen_US
dc.subjectCytotoxic activityen_US
dc.subjectMycochemistryen_US
dc.subjectIsolation and structural elucidationen_US
dc.subjectSpectroscopic techniquesen_US
dc.titleInsight into isolation and elucidation of cytotoxic ergostanoids from the mushroom Sarcosphaera crassa (Santi) Pouzar: An edible mushroomen_US
dc.titleInsight into isolation and elucidation of cytotoxic ergostanoids from the mushroom Sarcosphaera crassa (Santi) Pouzar: An edible mushroom
dc.typeArticleen_US

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