Nebivolol Ameliorates Hepatic Ischemia/Reperfusion Injury on Liver But Not on Distant Organs

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dc.contributor.authorUlger, Burak Veli
dc.contributor.authorErbis, Halil
dc.contributor.authorTurkcu, Gul
dc.contributor.authorEkinci, Aysun
dc.contributor.authorTurkoglu, Mehmet Akif
dc.contributor.authorEkinci, Cenap
dc.contributor.authorYilmaz, Vural Taner
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Hepatic ischemia/reperfusion injury may occur after large tumor resection and liver transplantation procedures. Nitric oxide was shown to have protective effects on ischemia/reperfusion injury. Nebivolol is a compound that has been reported to improve nitric oxide release. We evaluated the effects of nebivolol in a rat liver ischemia/reperfusion model. Methods: A total of 40 rats were randomly divided into four groups (n = 10 each). Group I underwent only laparotomy, Group II was administered nebivolol and then underwent laparotomy, Group III underwent laparotomy and hepatic ischemia/reperfusion, and Group IV was administered nebivolol and then underwent laparotomy and hepatic ischemia/reperfusion. Serum AST, ALT, urea, and creatinine levels, and TAS and TOS levels of liver, lung, and kidney tissues were determined. Histopathological determination was also performed. Results: Nebivolol significantly reduced liver function tests in group IV, but it did not improve renal functions. Oxidative stress and abnormal histopathological findings were found to be reduced in liver tissue in group IV. Although the oxidative stress was increased after hepatic ischemia/reperfusion, nebivolol could not reduce the oxidative stress in kidney tissue. There were no significant differences between group III and group IV in terms of the histopathological changes in kidney tissue. There were no significant differences in lung tissue between the groups. Conclusions: The results of this study suggest that nebivolol has protective effects on liver but not on distant organs in a hepatic ischemia/reperfusion injury model. These experimental findings indicate that nebivolol may be useful in the treatment of hepatic ischemia/reperfusion injury.en_US
dc.description.sponsorshipDicle University, Coordination of Scientific Research Projects [13-TF-97]en_US
dc.description.sponsorshipThis study was financially supported by Dicle University, Coordination of Scientific Research Projects (Project no: 13-TF-97).en_US
dc.identifier.doi10.3109/08941939.2015.1031923
dc.identifier.endpage252en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue5en_US
dc.identifier.pmid26305470en_US
dc.identifier.scopus2-s2.0-85027953917en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://doi.org/10.3109/08941939.2015.1031923
dc.identifier.urihttps://hdl.handle.net/11468/19077
dc.identifier.volume28en_US
dc.identifier.wosWOS:000369510000004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNebivololen_US
dc.subjectNitric Oxideen_US
dc.subjectHepatic Ischemiaen_US
dc.subjectReperfusion Injuryen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectLungen_US
dc.titleNebivolol Ameliorates Hepatic Ischemia/Reperfusion Injury on Liver But Not on Distant Organsen_US
dc.typeArticleen_US

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