Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis

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dc.contributor.authorYilmaz, Bulent
dc.contributor.authorKoklu, Seyfettin
dc.contributor.authorBuyukbayram, Huseyin
dc.contributor.authorYalcin, Kendal
dc.contributor.authorKorkmaz, Ugur
dc.contributor.authorPosul, Emrah
dc.contributor.authorCan, Guray
dc.date.accessioned2024-04-24T17:24:34Z
dc.date.available2024-04-24T17:24:34Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear.. Objectives: The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 included those with hepatic steatosis (n=28) and group 2 those without hepatic steatosis. The groups were compared in terms of age, body mass index (BMI), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), viral load, biochemical parameters and histological findings. Patients in group 1 were subdivided according to the degree of steatosis as follows: grade 1 (15 patients, 53.6%), grade 2 (6 patients, 21.4%), and grade 3 (7 patients, 25%). Results: In group 1 (n=28), mean age, BMI, cholesterol, and HOMA-IR were found to be significantly higher than in group 2 (n=60). There were no significant differences in the positivity of viral load, HbeAg, treatment, fibrosis and other laboratory parameters between the two groups. HOMA-IR was the only independent predictive factor of liver steatosis in patients with CHB in logistic regression analysis. Conclusion: Hepatic steatosis in CHB patients was associated with host metabolic factors.en_US
dc.identifier.doi10.4314/ahs.v15i3.3
dc.identifier.endpage718en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue3en_US
dc.identifier.pmid26957957
dc.identifier.scopus2-s2.0-84941331320
dc.identifier.scopusqualityQ2
dc.identifier.startpage714en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v15i3.3
dc.identifier.urihttps://hdl.handle.net/11468/19740
dc.identifier.volume15en_US
dc.identifier.wosWOS:000364819000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectLiver Steatosisen_US
dc.subjectHoma-Iren_US
dc.subjectBmien_US
dc.subjectBiopsyen_US
dc.titleChronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosisen_US
dc.titleChronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis
dc.typeArticleen_US

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