Urinary kidney injury molecules in children with iron-deficiency anemia

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dc.contributor.authorGüneş, Ali
dc.contributor.authorEce, Aydın
dc.contributor.authorAktar, Fesih
dc.contributor.authorTan, İlhan
dc.contributor.authorSöker, Murat
dc.contributor.authorKarabel, Duran
dc.contributor.authorBalık, Hasan
dc.contributor.authorUluca, Ünal
dc.contributor.authorŞen, Velat
dc.contributor.authorYolbaş, İlyas
dc.date.accessioned2024-04-24T17:56:37Z
dc.date.available2024-04-24T17:56:37Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the urine levels of human kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-?-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with iron-deficiency anemia (IDA). Material/Methods: Thirty-five children with IDA and 32 matched healthy controls were recruited. We assessed complete blood count, serum iron, iron-binding capacity, ferritin, serum levels of urea, creatinine (Cr), sodium (Na), potassium (K), calcium (Ca), and glucose levels. Estimated glomerular filtration rate (eGFR) was calculated. Urinary NAG, NGAL, KIM-1, and L-FABP were measured and divided by urine creatinine for comparisons. Results: There were no significant differences in serum urea, Cr, or eGFR between the IDA group and the control group (p> 0.05, for all). IDA patients had significantly higher urine NGAL/Cr, L-FABP/Cr, KIM-1/Cr, and NAG/Cr compared with the control group (p<0.05). There were significant negative correlations between hemoglobin, hematocrit, red blood cell count, and urine NGAL/Cr, NAG/Cr, L-FABP/Cr, KIM-1/Cr levels (p<0.05). Conclusions: Higher urinary kidney injury molecule levels in IDA patients suggest a possible subclinical renal injury in pediatric IDA patients whose renal functions and serum electrolytes were normal.en_US
dc.identifier.citationGüneş, A., Ece, A., Aktar, F., Tan, İ., Söker, M., Karabel, D. ve diğerleri. (2015). Urinary kidney injury molecules in children with iron-deficiency anemia. Medical Science Monitor, 21, 4023-4029.
dc.identifier.doi10.12659/MSM.896794
dc.identifier.endpage4029en_US
dc.identifier.issn1234-1010
dc.identifier.pmid26697893
dc.identifier.scopus2-s2.0-84952329530
dc.identifier.scopusqualityQ1
dc.identifier.startpage4023en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.896794
dc.identifier.urihttps://hdl.handle.net/11468/23594
dc.identifier.volume21en_US
dc.identifier.wosWoSIDEksik
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnemiaen_US
dc.subjectEarly diagnosisen_US
dc.subjectIron-deficiencyen_US
dc.subjectKidney diseasesen_US
dc.titleUrinary kidney injury molecules in children with iron-deficiency anemiaen_US
dc.titleUrinary kidney injury molecules in children with iron-deficiency anemia
dc.typeArticleen_US

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