Anti-hepatitis delta virus seroprevalence and risk factors in patients with hepatitis B in Southeast Turkey

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dc.contributor.authorCelen, MK
dc.contributor.authorAyaz, C
dc.contributor.authorHosoglu, S
dc.contributor.authorGeyik, MF
dc.contributor.authorUlug, M
dc.date.accessioned2024-04-24T17:33:14Z
dc.date.available2024-04-24T17:33:14Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To obtain regional epidemiological data on hepatitis delta virus (HDV, a defective virus) infections, the incidence of anti-HDV positivity and the associated risk factors in asymptomatic hepatitis B virus surface antigen (HBsAg) carriers and in patients with chronic active hepatitis B. Methods: The study took place at Dicle University Hospital (Diyarbakir, Southeast of Turkey) between January 2002 and July 2004. Anti-HDV screening was performed in asymptomatic hepatitis B carriers (N=889) and in patients with chronic active hepatitis B infection (N=120). We explored the association between anti-HDV positivity and asymptomatic hepatitis B carrier status, presence of active hepatitis B. age, gender, the durations of HBsAg positivity and hepatitis B e antigen (HBeAg) positivity. Results: In 6% of asymptomatic hepatitis B carriers (53/889) and in 27.5% of patients with chronic active hepatitis B (33/120) anti-HDV was positive. The incidence of anti-HDV positivity was significantly higher in patients with chronic active hepatitis B compared with asymptomatic carriers (p < 0.001). A significant association between the duration of HBsAg carrier status (3.2 +/- 1.4 years) and anti-HDV positivity was also found (p < 0.001). Age, gender, and HBeAg positivity were not significantly associated with anti-HDV positivity (p > 0.05). Conclusion: Anti-HDV positivity was significantly more common in patients with chronic hepatitis B compared with asymptomatic hepatitis B virus (HBV) carriers in a region with a high prevalence of HBV infection. We found a significant relationship between the duration of HBsAg carrier status and anti-HDV positively, however, age, gender, and presence of HBeAg were not significantly associated with the development of anti-HDV positivity.en_US
dc.identifier.endpage620en_US
dc.identifier.issn0379-5284
dc.identifier.issue5en_US
dc.identifier.pmid16680248
dc.identifier.scopus2-s2.0-33646585742
dc.identifier.scopusqualityQ2
dc.identifier.startpage617en_US
dc.identifier.urihttps://hdl.handle.net/11468/20559
dc.identifier.volume27en_US
dc.identifier.wosWOS:000237854300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleAnti-hepatitis delta virus seroprevalence and risk factors in patients with hepatitis B in Southeast Turkeyen_US
dc.titleAnti-hepatitis delta virus seroprevalence and risk factors in patients with hepatitis B in Southeast Turkey
dc.typeArticleen_US

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